HitPredict

Interactor 1: TLR4 (O00206)
Toll-like receptor 4 (hToll) (CD antigen CD284)
Gene: TLR4

Interactor 2: SFTPD (P35247)
Pulmonary surfactant-associated protein D (PSP-D) (SP-D) (Collectin-7) (Lung surfactant protein D)
Gene: SFTPD

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	16834340, 18990700
Identification Methods	solid phase assay, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LRR_8~Lectin_C
Common GO terms	GO:0042742 - defense response to bacterium GO:0045087 - innate immune response
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 839 Hs			1 375
+	Hs
		120128 TLR4_HUMAN (1-839): 1.38e-145: 451: 100.00		MBL2_HUMAN (170-375): 2.47e-38: 139: 37.92
+	Hs
		120164 TLR4_HUMAN (1-839): 1.38e-145: 451: 100.00		SFTA1_HUMAN (64-137): 2.37e-10: 62.2: 45.33
+	Hs
		120163 TLR4_HUMAN (1-839): 1.38e-145: 451: 100.00		SFPA2_HUMAN (52-117): 5.67e-09: 58: 38.36
+	Hs
		237475 TLR2_HUMAN (19-815): 1.12e-90: 305: 22.15		SFTPD_HUMAN (13-375): 2.05e-61: 203: 100.00
+	Hs
		237520 TLR2_HUMAN (19-815): 1.12e-90: 305: 22.15		CLC4M_HUMAN (243-374): 5.17e-41: 150: 22.22
+	Hs
		237504 TLR2_HUMAN (19-815): 1.12e-90: 305: 22.15		SFTA1_HUMAN (64-137): 2.37e-10: 62.2: 45.33
+	Hs
		1073323 TLR1_HUMAN (9-492): 9.13e-11: 67.5: 14.60		COL12_HUMAN (177-374): 2.09e-43: 161: 18.84
+	Hs
		179924 TLR3_HUMAN (3-164): 4.58e-09: 62.1: 17.54		MBL2_HUMAN (170-375): 2.47e-38: 139: 37.92