HitPredict

Interactor 1: SOX6 (P40645)
Transcription factor SOX-6 (SOX-LZ)
Gene: SOX6

Interactor 2: TOX3 (Q80W03)
TOX high mobility group box family member 3 (Trinucleotide repeat-containing gene 9 protein)
Gene: TOX3

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	20211142
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	HMG_box~HMG_box
Common GO terms	GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0042803 - protein homodimerization activity GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 827 Mm			1 575
+	Hs
		727933 SOX6_HUMAN (1-827): 0: 681: 96.01		HM20B_HUMAN (218-471): 2.36e-36: 140: 20.85
+	Hs
		727930 SOX6_HUMAN (1-827): 0: 681: 96.01		HM20A_HUMAN (164-469): 1.65e-34: 135: 12.26
+	Hs
		727910 SOX6_HUMAN (1-827): 0: 681: 96.01		CIC_HUMAN (8-436): 5.67e-30: 127: 13.45
+	Hs
		727813 SOX5_HUMAN (1-788): 1.2e-163: 495: 56.49		HM20B_HUMAN (218-471): 2.36e-36: 140: 20.85
+	Hs
		727705 SOX5_HUMAN (1-788): 1.2e-163: 495: 56.49		SOX6_HUMAN (13-463): 8.18e-33: 136: 10.40
+	Hs
		727808 SOX5_HUMAN (1-788): 1.2e-163: 495: 56.49		HM20A_HUMAN (164-469): 1.65e-34: 135: 12.26
+	Hs
		727788 SOX5_HUMAN (1-788): 1.2e-163: 495: 56.49		CIC_HUMAN (8-436): 5.67e-30: 127: 13.45
+	Mm
		727702 SOX5_MOUSE (1-788): 9.91e-161: 488: 56.37		SOX6_MOUSE (13-463): 2.65e-29: 125: 10.40
+	Hs
		996845 CIC_HUMAN (281-826): 1.44e-49: 192: 14.53		SSRP1_HUMAN (83-411): 1.17e-47: 179: 17.10
+	Hs
		881826 CIC_HUMAN (281-826): 1.44e-49: 192: 14.53		SOX10_HUMAN (160-561): 2.97e-29: 123: 12.78
+	Hs
		1300941 CIC_HUMAN (281-826): 1.44e-49: 192: 14.53		SOX17_HUMAN (201-483): 2.12e-28: 119: 11.93
+	Dm
		954936 PANG1_DROME (402-826): 6.29e-38: 154: 14.10		PANG1_DROME (58-328): 1.28e-31: 132: 12.38
+	Dm
		114457 M9PCG2_DROME (578-797): 5.55e-38: 152: 24.78		PANG1_DROME (58-328): 1.28e-31: 132: 12.38
+	Dm
		1212959 Q9VUD3_DROME (578-797): 5.74e-39: 155: 24.78		PANG2_DROME (48-507): 2.98e-29: 125: 11.26
+	Hs
		881788 SOX10_HUMAN (560-826): 2.05e-37: 148: 22.43		SOX10_HUMAN (160-561): 2.97e-29: 123: 12.78
+	Hs
		1281244 SOX17_HUMAN (556-814): 6.86e-40: 154: 27.44		SMCE1_HUMAN (260-542): 1.63e-27: 116: 15.49
+	Hs
		449817 TF7L2_HUMAN (305-800): 4.29e-41: 162: 12.84		HMGB1_HUMAN (247-386): 6.22e-17: 81.6: 16.20
+	Hs
		567772 TF7L2_HUMAN (305-800): 4.29e-41: 162: 12.84		UBF1_HUMAN (208-527): 3.84e-11: 68: 10.70