HitPredict

Interactor 1: UBP8 (P40818)
Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8)
Gene: USP8

Interactor 2: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	26507658
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1118 Hs			1 126
+	Hs
		271037 UBP2_HUMAN (527-1111): 7.7e-120: 384: 29.62		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		918801 UBP3_HUMAN (628-1113): 3.22e-115: 369: 25.05		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		707807 UBP3_HUMAN (628-1113): 3.22e-115: 369: 25.05		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		1087489 UBP22_HUMAN (744-1109): 3.1e-111: 358: 27.72		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		707794 UBP22_HUMAN (744-1109): 3.1e-111: 358: 27.72		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		905383 UBP46_HUMAN (767-1109): 5.5e-107: 341: 27.22		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		905394 UBP46_HUMAN (767-1109): 5.5e-107: 341: 27.22		H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41
+	Hs
		259286 UBP12_HUMAN (767-1110): 2.83e-106: 339: 27.70		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		707665 UBP51_HUMAN (728-1110): 1.45e-100: 336: 24.76		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		707745 UBP44_HUMAN (700-1109): 8.86e-99: 331: 24.35		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		707785 UBP21_HUMAN (605-1111): 9.13e-98: 323: 26.08		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		1282957 UBP44_HUMAN (700-1109): 8.86e-99: 331: 24.35		H2B1A_HUMAN (1-126): 3.43e-46: 147: 85.04
+	Hs
		1087213 UBP49_HUMAN (612-1115): 7.52e-92: 311: 20.68		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Sc
		355943 UBP8_YEAST (736-1107): 2.66e-97: 319: 26.08		H2B2_YEAST (3-125): 4.73e-37: 124: 71.55
+	Sc
		355547 UBP8_YEAST (736-1107): 2.66e-97: 319: 26.08		H2B1_YEAST (3-125): 1.81e-36: 122: 71.55
+	Hs
		1087506 UBP15_HUMAN (964-1106): 1.96e-34: 145: 49.65		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00