Interactor 1: ECHA (P40939)
Trifunctional enzyme subunit alpha, mitochondrial (78 kDa gastrin-binding protein) (Monolysocardiolipin acyltransferase) (EC 2.3.1.-) (TP-alpha) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)]
Gene: HADHA

Interactor 2: ECHB (P55084)
Trifunctional enzyme subunit beta, mitochondrial (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.155) (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)]
Gene: HADHB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.81 1.00 0.903

The method score is based on:

Property Details
Experiments 28514442, 24981860, 33961781, 30850536
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, x-ray crystallography, molecular sieving
Interaction Type physical association, association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains 3HCDH_N~Thiolase_N, ECH_1~Thiolase_C, ECH_1~Thiolase_N
Common GO terms GO:0003857 - 3-hydroxyacyl-CoA dehydrogenase activity
GO:0003985 - acetyl-CoA C-acetyltransferase activity
GO:0004300 - enoyl-CoA hydratase activity
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
and 3 others

more...

Homologous interactions 5

Homologous interactions

Color coding for hit scores

1 763
Hs

1 474
+ Dm
+ Ec
+ Hs
+ Hs
+ At

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024