HitPredict

Interactor 1: VATE1 (P36543)
V-type proton ATPase subunit E 1 (V-ATPase subunit E 1) (V-ATPase 31 kDa subunit) (p31) (Vacuolar proton pump subunit E 1)
Gene: ATP6V1E1

Interactor 2: VPP2 (Q9Y487)
V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa subunit a 2) (Lysosomal H(+)-transporting ATPase V0 subunit a 2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2)
Gene: ATP6V0A2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.839

Property	Details
Experiments	28514442, 33961781, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	V_ATPase_I~vATP-synt_E
Common GO terms	GO:0005765 - lysosomal membrane GO:0016241 - regulation of macroautophagy GO:0046961 - proton-transporting ATPase activity, rotational mechanism GO:0051117 - ATPase binding GO:1902600 - proton transmembrane transport
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 226 Hs			1 856
+	Hs
		1381839 VATE2_HUMAN (1-225): 2.26e-90: 266: 76.89		VPP2_HUMAN (1-856): 0: 1321: 100.00
+	Hs
		784800 VATE1_HUMAN (1-226): 1.06e-103: 300: 100.00		VPP1_HUMAN (1-842): 0: 1278: 53.19
+	Hs
		1371944 VATE2_HUMAN (1-225): 2.26e-90: 266: 76.89		VPP1_HUMAN (1-842): 0: 1278: 53.19
+	Hs
		784807 VATE1_HUMAN (1-226): 1.06e-103: 300: 100.00		VPP4_HUMAN (1-843): 0: 1227: 51.89
+	Hs
		1381837 VATE2_HUMAN (1-225): 2.26e-90: 266: 76.89		VPP4_HUMAN (1-843): 0: 1227: 51.89
+	Hs
		784787 VATE1_HUMAN (1-226): 1.06e-103: 300: 100.00		VPP3_HUMAN (1-843): 0: 1082: 49.35
+	Sc
		645806 VATE_YEAST (2-226): 4.69e-76: 230: 33.48		VPP1_YEAST (3-842): 0: 1037: 36.46
+	Sc
		645813 VATE_YEAST (2-226): 4.69e-76: 230: 33.48		VPP2_YEAST (3-845): 0: 947: 33.19