HitPredict

Interactor 1: ACTY (P42025)
Beta-centractin (Actin-related protein 1B) (ARP1B)
Gene: ACTR1B

Interactor 2: ARP10 (Q9NZ32)
Actin-related protein 10 (Actin-related protein 11) (hARP11)
Gene: ACTR10

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Actin
Common GO terms	GO:0005576 - extracellular region GO:0005829 - cytosol GO:0005869 - dynactin complex GO:1904813 - ficolin-1-rich granule lumen
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 376 Hs			1 417
+	Hs
		897139 ACTZ_HUMAN (1-376): 0: 728: 90.43		ARP10_HUMAN (1-417): 0: 565: 100.00
+	Hs
		785527 ACTY_HUMAN (1-376): 0: 776: 100.00		ACTG_HUMAN (10-384): 2.53e-173: 491: 24.44
+	Hs
		785529 ACTY_HUMAN (1-376): 0: 776: 100.00		ACTC_HUMAN (7-384): 4e-172: 487: 24.51
+	Hs
		891655 ACTZ_HUMAN (1-376): 0: 728: 90.43		ACTB_HUMAN (10-384): 1.71e-173: 491: 23.94
+	Hs
		897031 ACTZ_HUMAN (1-376): 0: 728: 90.43		ACTG_HUMAN (10-384): 2.53e-173: 491: 24.44
+	Hs
		897033 ACTZ_HUMAN (1-376): 0: 728: 90.43		ACTC_HUMAN (7-384): 4e-172: 487: 24.51
+	Hs
		897029 ACTZ_HUMAN (1-376): 0: 728: 90.43		ACTA_HUMAN (7-384): 4.62e-171: 485: 24.26
+	Dm
		361129 ACT4_DROME (8-376): 0: 603: 53.35		ACT2_DROME (8-384): 4.24e-173: 490: 24.57
+	Dm
		361164 ACT4_DROME (8-376): 0: 603: 53.35		ACT5_DROME (8-383): 2.8e-173: 490: 24.88
+	Dm
		361177 ACT4_DROME (8-376): 0: 603: 53.35		ACT3_DROME (8-383): 6.35e-173: 489: 25.12
+	Dm
		361179 ACT4_DROME (8-376): 0: 603: 53.35		ACT6_DROME (8-383): 4.85e-172: 487: 24.88
+	Sp
		501575 ACT_SCHPO (10-376): 0: 603: 52.83		ACT_SCHPO (10-383): 1.3e-170: 484: 24.25
+	Sc
		887643 ACT_YEAST (10-376): 0: 602: 52.56		ACT_YEAST (10-384): 2.79e-170: 483: 23.94
+	Gg
		891646 ACTB_CHICK (8-376): 0: 581: 53.62		ACTB_CHICK (10-384): 1.71e-173: 491: 23.94
+	Hs
		891675 ACTG_HUMAN (7-376): 0: 581: 53.74		ACTB_HUMAN (10-384): 1.71e-173: 491: 23.94
+	Hs
		929815 ACTG_HUMAN (7-376): 0: 581: 53.74		ACTG_HUMAN (10-384): 2.53e-173: 491: 24.44
+	Hs
		929883 Q1KLZ0_HUMAN (8-376): 0: 581: 53.62		ACTG_HUMAN (10-384): 2.53e-173: 491: 24.44
+	Hs
		929817 ACTG_HUMAN (7-376): 0: 581: 53.74		ACTC_HUMAN (7-384): 4e-172: 487: 24.51
+	Hs
		929816 ACTG_HUMAN (7-376): 0: 581: 53.74		ACTH_HUMAN (8-384): 2.65e-170: 483: 24.57
+	Dm
		800145 ACTZ_DROME (1-376): 0: 641: 77.13		Q9VWE8_DROME (1-394): 1.1e-92: 285: 40.25