HitPredict

Interactor 1: STA5A (P42229)
Signal transducer and activator of transcription 5A
Gene: STAT5A

Interactor 2: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	10617656, 12060651
Identification Methods	pull down, enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~SH2, SH2~Y_phosphatase
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0019221 - cytokine-mediated signaling pathway
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 794 Hs			1 593
+	Mm
		719288 STA5A_MOUSE (1-794): 0: 1043: 96.35		PTN11_MOUSE (1-593): 0: 580: 99.49
+	Hs
		849884 STA5B_HUMAN (1-774): 0: 997: 93.84		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		665833 STA5B_HUMAN (1-774): 0: 997: 93.84		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		573605 STA5A_HUMAN (1-794): 0: 1050: 100.00		PTN1_HUMAN (232-541): 4.38e-110: 338: 31.63
+	Hs
		786325 STAT1_HUMAN (1-724): 0: 755: 28.09		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		573623 STA5B_HUMAN (1-774): 0: 997: 93.84		PTN1_HUMAN (232-541): 4.38e-110: 338: 31.63
+	Hs
		776659 STAT3_HUMAN (1-723): 0: 736: 29.94		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Mm
		665977 STAT1_MOUSE (1-724): 0: 757: 27.87		PTN6_MOUSE (6-583): 0: 530: 55.94
+	Hs
		665813 STAT3_HUMAN (1-723): 0: 736: 29.94		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Mm
		665978 STAT3_MOUSE (1-723): 0: 737: 29.94		PTN6_MOUSE (6-583): 0: 530: 55.94
+	Mm
		786649 STA5A_MOUSE (1-794): 0: 1043: 96.35		PTN2_MOUSE (263-518): 2.21e-50: 181: 39.00
+	Mm
		786664 STA5B_MOUSE (1-774): 0: 985: 92.17		PTN2_MOUSE (263-518): 2.21e-50: 181: 39.00
+	Hs
		573602 STAT3_HUMAN (1-723): 0: 736: 29.94		PTN1_HUMAN (232-541): 4.38e-110: 338: 31.63
+	Hs
		146922 STAT3_HUMAN (1-723): 0: 736: 29.94		PTPRT_HUMAN (35-524): 6.59e-70: 247: 18.90
+	Hs
		570492 STAT1_HUMAN (1-724): 0: 755: 28.09		PTN2_HUMAN (263-518): 6.71e-51: 182: 39.00
+	Hs
		570489 STAT3_HUMAN (1-723): 0: 736: 29.94		PTN2_HUMAN (263-518): 6.71e-51: 182: 39.00
+	Hs
		570493 STAT6_HUMAN (1-766): 0: 720: 37.71		PTN2_HUMAN (263-518): 6.71e-51: 182: 39.00