Protein: GRB10
Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR)

Gene: GRB10
Organism: Homo sapiens
Interactions: 166
UniProt ID: Q13322

Gene Ontology (top 5):
GO:0005158 - insulin receptor binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0008286 - insulin receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

439723

INSR
Insulin receptor

11

20

Small-scale

0.981

High

465509

IGF1R
Insulin-like growth factor 1 receptor

6

20

Small-scale

0.946

High

1102318

GRB10
Growth factor receptor-bound protein 10

5

20

Small-scale

0.921

High

363223

EGFR
Epidermal growth factor receptor

4

20

Small-scale

0.897

High

463953

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

3

20

Small-scale

0.880

High

557281

SRC
Proto-oncogene tyrosine-protein kinase Src

3

20

Small-scale

0.861

High

400773

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

20

Small-scale

0.845

High

1102335

WDR59
GATOR2 complex protein WDR59

2

7

High-throughput

0.811

High

840910

TXK
Tyrosine-protein kinase TXK

2

20

High-throughput

0.783

High

902832

BLK
Tyrosine-protein kinase Blk

2

18

High-throughput

0.783

High

1102319

TNK1
Non-receptor tyrosine-protein kinase TNK1

2

20

High-throughput

0.783

High

1102377

PICK1
PRKCA-binding protein

2

3

High-throughput

0.783

High

987609

GRB2
Growth factor receptor-bound protein 2

2

20

High-throughput

0.776

High

772494

IRS1
Insulin receptor substrate 1

2

20

Small-scale

0.768

High

1102385

BAIP2
BAR/IMD domain-containing adapter protein 2

2

12

High-throughput

0.767

High

699733

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

20

Small-scale

0.754

High

1102365

NED4L
E3 ubiquitin-protein ligase NEDD4-like

2

16

Small-scale

0.754

High

1102388

IRS2
Insulin receptor substrate 2

2

20

Small-scale

0.754

High

932031

EPHB1
Ephrin type-B receptor 1

1

20

Small-scale

0.751

High

532077

KIT
Mast/stem cell growth factor receptor Kit

1

20

Small-scale

0.740

High

1038289

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

20

Small-scale

0.740

High

964603

DCAF7
DDB1- and CUL4-associated factor 7

2

4

High-throughput

0.737

High

1102367

GRWD1
Glutamate-rich WD repeat-containing protein 1

2

4

High-throughput

0.737

High

1102372

SKI8
Superkiller complex protein 8

2

3

High-throughput

0.737

High

1102374

WDR6
tRNA

2

12

High-throughput

0.737

High

728212

AKT1
RAC-alpha serine/threonine-protein kinase

1

20

Small-scale

0.734

High

966271

1433G
14-3-3 protein gamma

4

20

High-throughput

0.694

High

1049255

1433F
14-3-3 protein eta

4

20

High-throughput

0.691

High

787013

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

20

Small-scale

0.690

High

971479

1433E
14-3-3 protein epsilon

3

6

Small-scale

0.674

High

1096423

PAK1
Serine/threonine-protein kinase PAK 1

1

20

High-throughput

0.665

High

281316

GGYF1
GRB10-interacting GYF protein 1

3

11

Small-scale

0.661

High

1102333

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

3

5

High-throughput

0.650

High

362277

ABL1
Tyrosine-protein kinase ABL1

1

20

Small-scale

0.647

High

410812

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

440538

FYN
Tyrosine-protein kinase Fyn

1

19

Small-scale

0.647

High

1102326

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

1102344

ABI1
Abl interactor 1

1

20

Small-scale

0.647

High

1102337

GGYF2
GRB10-interacting GYF protein 2

3

20

Small-scale

0.641

High

730562

1433S
14-3-3 protein sigma

3

20

High-throughput

0.633

High

778061

VGFR2
Vascular endothelial growth factor receptor 2

1

20

Small-scale

0.621

High

854031

KI67
Proliferation marker protein Ki-67

1

11

High-throughput

0.618

High

253346

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.618

High

373909

RASN
GTPase NRas

1

20

Small-scale

0.618

High

533847

GHR
Growth hormone receptor

1

20

Small-scale

0.618

High

1102330

NTRK2
BDNF/NT-3 growth factors receptor

1

20

Small-scale

0.618

High

1102338

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

1102379

HECW2
E3 ubiquitin-protein ligase HECW2

1

16

High-throughput

0.618

High

1102384

SHAN2
SH3 and multiple ankyrin repeat domains protein 2

1

20

Small-scale

0.618

High

1102380

RCAN3
Calcipressin-3

2

0

High-throughput

0.607

High

138680

IMA4
Importin subunit alpha-4

2

2

High-throughput

0.606

High

334408

SYFM
Phenylalanine--tRNA ligase, mitochondrial

2

2

High-throughput

0.606

High

1102332

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

16

High-throughput

0.606

High

1102363

AP4AT
AP-4 complex accessory subunit Tepsin

2

1

High-throughput

0.606

High

932063

EPHA4
Ephrin type-A receptor 4

1

20

High-throughput

0.590

High

1102329

SNAT
Serotonin N-acetyltransferase

2

0

High-throughput

0.580

High

1102360

ZMY19
Zinc finger MYND domain-containing protein 19

2

0

High-throughput

0.580

High

1102361

CHFR
E3 ubiquitin-protein ligase CHFR

1

3

Small-scale

0.579

High

484126

PGFRB
Platelet-derived growth factor receptor beta

1

20

Small-scale

0.575

High

134291

RPOM
DNA-directed RNA polymerase, mitochondrial

2

1

High-throughput

0.571

High

177210

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

2

7

High-throughput

0.571

High

343941

HS74L
Heat shock 70 kDa protein 4L

2

20

High-throughput

0.571

High

346999

BAG2
BAG family molecular chaperone regulator 2

2

3

High-throughput

0.571

High

348489

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

1

High-throughput

0.571

High

415538

HSPB1
Heat shock protein beta-1

2

10

High-throughput

0.571

High

428131

RLA1
Large ribosomal subunit protein P1

2

2

High-throughput

0.571

High

452249

PDIA1
Protein disulfide-isomerase

2

10

High-throughput

0.571

High

507185

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

10

High-throughput

0.571

High

507920

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

10

High-throughput

0.571

High

535014

BIP
Endoplasmic reticulum chaperone BiP

2

20

High-throughput

0.571

High

537098

HSP7C
Heat shock cognate 71 kDa protein

2

18

High-throughput

0.571

High

577740

PLAK
Junction plakoglobin

2

18

High-throughput

0.571

High

593840

PP2BB
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

2

12

High-throughput

0.571

High

600804

HSP76
Heat shock 70 kDa protein 6

2

18

High-throughput

0.571

High

629834

BTF3
Transcription factor BTF3

2

3

High-throughput

0.571

High

646703

CADH3
Cadherin-3

2

14

High-throughput

0.571

High

697519

PYR1
Multifunctional protein CAD

2

7

High-throughput

0.571

High

717794

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

2

4

High-throughput

0.571

High

761664

HSP74
Heat shock 70 kDa protein 4

2

20

High-throughput

0.571

High

764323

CTNA1
Catenin alpha-1

2

5

High-throughput

0.571

High

764721

CTNB1
Catenin beta-1

2

10

High-throughput

0.571

High

801300

HSPA9
Stress-70 protein, mitochondrial

2

20

High-throughput

0.571

High

859262

RL5
Large ribosomal subunit protein uL18

2

2

High-throughput

0.571

High

868084

AL1A3
Retinaldehyde dehydrogenase 3

2

1

High-throughput

0.571

High

899878

FXR1
RNA-binding protein FXR1

2

7

High-throughput

0.571

High

907411

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

2

12

High-throughput

0.571

High

964108

RL37
Large ribosomal subunit protein eL37

2

1

High-throughput

0.571

High

987350

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

2

7

High-throughput

0.571

High

991019

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

2

5

High-throughput

0.571

High

991979

RL38
Large ribosomal subunit protein eL38

2

1

High-throughput

0.571

High

994206

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

2

7

High-throughput

0.571

High

1062364

PP2BA
Protein phosphatase 3 catalytic subunit alpha

2

17

High-throughput

0.571

High

1102320

RBM39
RNA-binding protein 39

2

17

High-throughput

0.571

High

1102321

FAT1
Protocadherin Fat 1

2

8

High-throughput

0.571

High

1102322

CUL7
Cullin-7

2

2

High-throughput

0.571

High

1102323

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

2

9

High-throughput

0.571

High

1102327

SC23B
Protein transport protein Sec23B

2

3

High-throughput

0.571

High

1102328

TRIP6
Thyroid receptor-interacting protein 6

2

20

High-throughput

0.571

High

1102331

SRSF7
Serine/arginine-rich splicing factor 7

2

14

High-throughput

0.571

High

1102339

DHX30
ATP-dependent RNA helicase DHX30

2

6

High-throughput

0.571

High

1102355

HS105
Heat shock protein 105 kDa

2

20

High-throughput

0.571

High

1102358

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

2

8

High-throughput

0.571

High

1102368

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

2

15

High-throughput

0.571

High

1102370

GTPB4
GTP-binding protein 4

2

5

High-throughput

0.571

High

1102371

DDX24
ATP-dependent RNA helicase DDX24

2

11

High-throughput

0.571

High

1102381

AKP8L
A-kinase anchor protein 8-like

2

1

High-throughput

0.571

High

1102382

G3BP2
Ras GTPase-activating protein-binding protein 2

2

10

High-throughput

0.571

High

1102387

EXOS1
Exosome complex component CSL4

2

1

High-throughput

0.571

High

1102389

IF2B2
Insulin-like growth factor 2 mRNA-binding protein 2

2

20

High-throughput

0.571

High

1102349

IKBD
NF-kappa-B inhibitor delta

2

17

High-throughput

0.553

High

1102352

TEKT4
Tektin-4

2

1

High-throughput

0.553

High

291997

CRTAP
Cartilage-associated protein

2

0

High-throughput

0.547

High

1102334

CDC73
Parafibromin

2

0

High-throughput

0.547

High

1102346

PAF1
RNA polymerase II-associated factor 1 homolog

2

0

High-throughput

0.547

High

1102376

EXOS3
Exosome complex component RRP40

2

0

High-throughput

0.547

High

1102359

TRI63
E3 ubiquitin-protein ligase TRIM63

1

20

High-throughput

0.541

High

1102369

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.541

High

1102356

CNOT9
CCR4-NOT transcription complex subunit 9

1

0

Small-scale

0.537

High

990182

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

1102342

AHNK2
Protein AHNAK2

1

11

High-throughput

0.536

High

1102364

RILP
Rab-interacting lysosomal protein

1

1

High-throughput

0.536

High

521671

H14
Histone H1.4

2

5

High-throughput

0.521

High

541997

TOP1
DNA topoisomerase 1

2

1

High-throughput

0.521

High

595761

H13
Histone H1.3

2

5

High-throughput

0.521

High

596078

H12
Histone H1.2

2

5

High-throughput

0.521

High

855069

NOP2
28S rRNA

2

1

High-throughput

0.521

High

1102343

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

2

7

High-throughput

0.521

High

1102366

EBP2
Probable rRNA-processing protein EBP2

2

1

High-throughput

0.521

High

1102373

GRPE1
GrpE protein homolog 1, mitochondrial

2

1

High-throughput

0.521

High

1102378

RBM28
RNA-binding protein 28

2

9

High-throughput

0.521

High

1102383

L10K
Leydig cell tumor 10 kDa protein homolog

2

1

High-throughput

0.521

High

370652

FOS
Protein c-Fos

1

2

High-throughput

0.515

High

384408

CRYAA
Alpha-crystallin A chain

1

10

High-throughput

0.515

High

570414

GFAP
Glial fibrillary acidic protein

1

20

High-throughput

0.515

High

1102324

SETB1
Histone-lysine N-methyltransferase SETDB1

1

6

High-throughput

0.515

High

1102350

LMO3
LIM domain only protein 3

1

20

High-throughput

0.515

High

1102353

JPH3
Junctophilin-3

1

4

High-throughput

0.515

High

1102325

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.513

High

1102347

CCYL1
Cyclin-Y-like protein 1

1

0

High-throughput

0.513

High

1102375

NRN1
Neuritin

1

0

High-throughput

0.513

High

1102362

MEG10
Multiple epidermal growth factor-like domains protein 10

1

13

Small-scale

0.508

High

422047

A4
Amyloid-beta precursor protein

1

14

High-throughput

0.501

High

1041043

CAV1
Caveolin-1

1

8

Small-scale

0.501

High

1102341

ZDH17
Palmitoyltransferase ZDHHC17

1

13

High-throughput

0.494

High

895319

GATM
Glycine amidinotransferase, mitochondrial

1

0

High-throughput

0.493

High

706116

S10A2
Protein S100-A2

1

5

High-throughput

0.489

High

848253

MAGA3
Melanoma-associated antigen 3

1

5

High-throughput

0.489

High

172775

XPO1
Exportin-1

1

8

High-throughput

0.479

High

377563

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

2

High-throughput

0.479

High

642844

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

11

Small-scale

0.479

High

665039

IL4RA
Interleukin-4 receptor subunit alpha

1

20

Small-scale

0.479

High

728677

IL2RG
Cytokine receptor common subunit gamma

1

20

Small-scale

0.479

High

861594

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

16

Small-scale

0.479

High

1102336

RICTR
Rapamycin-insensitive companion of mTOR

1

2

High-throughput

0.479

High

1102357

HDAC2
Histone deacetylase 2

1

11

High-throughput

0.479

High

1102340

Q86V38
Atrophin 1

1

12

High-throughput

0.470

High

274939

TM127
Transmembrane protein 127

1

0

Small-scale

0.458

High

877479

HSP77
Putative heat shock 70 kDa protein 7

1

20

High-throughput

0.445

High

1023768

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

5

High-throughput

0.445

High

566657

PDIA4
Protein disulfide-isomerase A4

1

9

High-throughput

0.407

High

1102345

MIA40
Mitochondrial intermembrane space import and assembly protein 40

2

0

High-throughput

0.298

High

1102351

TFB1M
Dimethyladenosine transferase 1, mitochondrial

2

0

High-throughput

0.298

High

1102354

H1X
Histone H1.10

2

0

High-throughput

0.298

High

1102386

RCL1
RNA 3'-terminal phosphate cyclase-like protein

2

0

High-throughput

0.298

High

1102348

NOA1
Nitric oxide-associated protein 1

1

0

High-throughput

0.265

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025