HitPredict

Interactor 1: PK3CA (P42336)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide 3-kinase alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1)
Gene: PIK3CA

Interactor 2: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.857

Property	Details
Experiments	9565634, 26839216, 9660791
Identification Methods	affinity chromatography technology, far western blotting
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PI3_PI4_kinase~SH2, PI3K_C2~SH2, PI3Ka~SH2
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007173 - epidermal growth factor receptor signaling pathway GO:0031295 - T cell costimulation
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 1068 Hs			1 593
+	Hs
		617159 PK3CA_HUMAN (1-1068): 0: 1325: 100.00		PTPRZ_HUMAN (33-537): 1.15e-65: 235: 16.73
+	Hs
		822540 PK3CG_HUMAN (1-1062): 0: 905: 32.08		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		944351 PRKDC_HUMAN (477-1017): 1.25e-91: 325: 17.90		PTPRU_HUMAN (33-528): 3.63e-66: 236: 18.48