Interactor 1: LIFR (P42703)
Leukemia inhibitory factor receptor (LIF receptor) (LIF-R) (D-factor/LIF receptor) (CD antigen CD118)
Gene: LIFR

Interactor 2: IL6RB (Q00560)
Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
Gene: Il6st

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.38 1.00 0.618

The method score is based on:

Property Details
Experiments 16452727
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains fn3~fn3, IL6Ra-bind~fn3
Common GO terms GO:0004896 - cytokine receptor activity
GO:0004923 - leukemia inhibitory factor receptor activity
GO:0004924 - oncostatin-M receptor activity
GO:0005127 - ciliary neurotrophic factor receptor binding
GO:0008284 - positive regulation of cell population proliferation
and 4 others

more...

Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 1092
Mm

1 917
+ Hs
+ Mm
+ Hs
+ Mm
+ Rn
+ Hs
+ Hs
+ Hs
+ Mm
+ Mm
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Dm
+ Dm
+ Mm
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024