HitPredict

Interactor 1: PI2R (P43119)
Prostacyclin receptor (Prostaglandin I2 receptor) (PGI receptor) (PGI2 receptor) (Prostanoid IP receptor)
Gene: PTGIR

Interactor 2: NHRF3 (Q5T2W1)
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (NHERF-3) (CFTR-associated protein of 70 kDa) (Na(+)/H(+) exchanger regulatory factor 3) (Na/Pi cotransporter C-terminal-associated protein 1) (NaPi-Cap1) (PDZ domain-containing protein 1) (Sodium-hydrogen exchanger regulatory factor 3)
Gene: PDZK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	21653824
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 386 Hs			1 519
+	Hs
		722923 SSR5_HUMAN (24-336): 1.84e-66: 216: 17.61		NHRF3_HUMAN (1-519): 1.87e-114: 350: 100.00
+	Hs
		1029371 PD2R_HUMAN (40-301): 1.87e-94: 288: 43.82		SCRIB_HUMAN (125-505): 6.83e-20: 96: 10.97
+	Rn
		495779 ADRB2_RAT (5-375): 3.49e-74: 238: 12.53		DLG4_RAT (3-344): 2.03e-36: 145: 17.22
+	Rn
		677498 SSR4_RAT (19-373): 6.63e-72: 231: 15.92		DLG4_RAT (3-344): 2.03e-36: 145: 17.22
+	Hs
		793194 PI2R_HUMAN (1-386): 1.72e-74: 237: 100.00		NHRF4_HUMAN (120-505): 7.2e-35: 139: 23.33
+	Mm
		830267 SSR4_MOUSE (19-373): 5.83e-71: 229: 17.04		DLG4_MOUSE (3-344): 3.77e-36: 144: 16.96
+	Hs
		441650 ADRB1_HUMAN (2-380): 3.48e-66: 219: 13.65		DLG4_HUMAN (3-344): 2.27e-36: 145: 17.22
+	Mm
		676818 SSR2_MOUSE (2-340): 3.76e-67: 218: 13.95		DLG4_MOUSE (3-344): 3.77e-36: 144: 16.96
+	Hs
		600726 DRD1_HUMAN (30-371): 1.46e-65: 216: 16.58		DLG4_HUMAN (3-344): 2.27e-36: 145: 17.22
+	Hs
		153858 ADRB2_HUMAN (5-376): 1.54e-72: 233: 14.29		NHRF1_HUMAN (5-134): 6.99e-24: 104: 31.54
+	Hs
		793199 PI2R_HUMAN (1-386): 1.72e-74: 237: 100.00		LNX1_HUMAN (4-213): 1.57e-20: 97.1: 16.74
+	Hs
		429050 ADRB2_HUMAN (5-376): 1.54e-72: 233: 14.29		NHRF2_HUMAN (5-146): 7.72e-20: 92.8: 28.17
+	Mm
		830268 SSR4_MOUSE (19-373): 5.83e-71: 229: 17.04		DLG2_MOUSE (297-459): 1.94e-19: 94.1: 21.77
+	Hs
		441656 ADRB1_HUMAN (2-380): 3.48e-66: 219: 13.65		MAGI1_HUMAN (183-460): 1.21e-20: 98.3: 19.89
+	Hs
		626687 ADA1D_HUMAN (16-383): 2.1e-63: 214: 14.95		SCRIB_HUMAN (125-505): 6.83e-20: 96: 10.97
+	Mm
		578603 ADRB2_MOUSE (5-375): 3.24e-74: 238: 12.53		MAGI3_MOUSE (89-503): 4.34e-10: 64.8: 12.88
+	Hs
		429068 ADRB2_HUMAN (5-376): 1.54e-72: 233: 14.29		MAGI3_HUMAN (174-503): 8.59e-11: 67.1: 13.01
+	Hs
		626682 ADA1D_HUMAN (16-383): 2.1e-63: 214: 14.95		DLG1_HUMAN (289-461): 1.6e-16: 85.1: 18.52
+	Hs
		441654 ADRB1_HUMAN (2-380): 3.48e-66: 219: 13.65		MAGI2_HUMAN (76-502): 3.32e-13: 74.8: 12.13
+	Hs
		441653 ADRB1_HUMAN (2-380): 3.48e-66: 219: 13.65		MAGI3_HUMAN (174-503): 8.59e-11: 67.1: 13.01