HitPredict

Interactor 1: MUC18 (P43121)
Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146)
Gene: MCAM

Interactor 2: NECT3 (Q9NQS3)
Nectin-3 (CDw113) (Nectin cell adhesion molecule 3) (Poliovirus receptor-related protein 3) (CD antigen CD113)
Gene: NECTIN3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	38117590
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C2-set_2~C2-set_2, C2-set_2~V-set, C2-set_2~Ig_3, Ig_3~V-set, V-set~V-set
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 646 Hs			1 549
+	Hs
		793426 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		KIRR1_HUMAN (41-509): 3.57e-62: 219: 17.59
+	Hs
		793412 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		NECT2_HUMAN (25-360): 1.8e-62: 215: 28.81
+	Hs
		793290 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		CNTN1_HUMAN (56-506): 2.46e-45: 173: 13.79
+	Ce
		103933 SAX3_CAEEL (6-637): 7.59e-95: 319: 14.96		SAX3_CAEEL (10-520): 1.71e-58: 212: 12.10
+	Hs
		793551 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		ROBO1_HUMAN (264-548): 5.78e-25: 112: 10.39
+	Hs
		530143 NCAM1_HUMAN (11-644): 1.38e-81: 277: 15.63		NCAM1_HUMAN (2-511): 1.22e-57: 208: 12.43
+	Hs
		1336275 ROBO2_HUMAN (1-646): 1.16e-96: 325: 14.69		ROBO1_HUMAN (264-548): 5.78e-25: 112: 10.39
+	Hs
		1336269 ROBO2_HUMAN (1-646): 1.16e-96: 325: 14.69		ROBO2_HUMAN (264-503): 6.31e-25: 111: 12.11
+	Mm
		1149039 CNTN4_MOUSE (20-612): 2.95e-44: 172: 15.30		CNTN4_MOUSE (38-544): 6.27e-50: 187: 12.33
+	Dr
		3062 A0A0R4IT86_DANRE (141-556): 2.07e-48: 183: 16.17		A0A0R4IT86_DANRE (2-507): 4.11e-46: 174: 12.22
+	Mm
		1206820 PTK7_MOUSE (141-613): 9.65e-54: 201: 15.07		PTK7_MOUSE (172-548): 1.66e-38: 153: 12.71
+	Mm
		530206 CNTN2_MOUSE (17-604): 4.83e-56: 207: 11.82		NCAM1_MOUSE (176-548): 2.41e-36: 146: 10.35
+	Mm
		530211 PTK7_MOUSE (141-613): 9.65e-54: 201: 15.07		NCAM1_MOUSE (176-548): 2.41e-36: 146: 10.35
+	Hs
		1018289 CNTN1_HUMAN (19-642): 1.11e-44: 173: 13.26		CNTN1_HUMAN (56-506): 2.46e-45: 173: 13.79
+	Hs
		970115 CNTN2_HUMAN (266-635): 1.01e-44: 173: 13.04		CNTN1_HUMAN (56-506): 2.46e-45: 173: 13.79
+	Mm
		530200 NCAM1_MOUSE (255-646): 5.9e-53: 198: 14.98		NCAM1_MOUSE (176-548): 2.41e-36: 146: 10.35
+	Dm
		1372760 Q9VQW1_DROME (25-515): 2.98e-39: 157: 15.24		Q9VQW1_DROME (171-413): 1.77e-18: 91.5: 14.29
+	Dm
		1372761 Q9VQW1_DROME (25-515): 2.98e-39: 157: 15.24		Q9VQW7_DROME (231-477): 6.27e-18: 90: 12.86
+	Dm
		89 A0A023GPK8_DROME (25-515): 1.79e-38: 155: 15.24		A0A023GPK8_DROME (171-413): 4.06e-18: 90.4: 14.29