HitPredict

Interactor 1: GRIK1 (P39086)
Glutamate receptor ionotropic, kainate 1 (GluK1) (Excitatory amino acid receptor 3) (EAA3) (Glutamate receptor 5) (GluR-5) (GluR5)
Gene: GRIK1

Interactor 2: DLG4 (P78352)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	12597860
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007268 - chemical synaptic transmission GO:0007399 - nervous system development GO:0098839 - postsynaptic density membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 918 Hs			1 724
+	Hs
		1006057 GRIK2_HUMAN (6-913): 0: 861: 76.02		DLG4_HUMAN (1-724): 0: 660: 100.00
+	Rn
		723862 GRIK2_RAT (12-913): 0: 858: 76.19		DLG4_RAT (1-724): 0: 661: 99.86
+	Mm
		811304 GRIK2_MOUSE (12-913): 0: 858: 76.19		DLG4_MOUSE (1-724): 0: 660: 99.59
+	Hs
		1092405 GRIK2_HUMAN (6-913): 0: 861: 76.02		DLG3_HUMAN (28-724): 0: 593: 64.92
+	Hs
		1091485 GRIK2_HUMAN (6-913): 0: 861: 76.02		DLG1_HUMAN (32-724): 0: 572: 73.33
+	Rn
		623648 GRIA1_RAT (14-913): 0: 749: 37.15		DLG4_RAT (1-724): 0: 661: 99.86
+	Mm
		1223787 GRIA4_MOUSE (20-918): 0: 748: 36.12		DLG4_MOUSE (1-724): 0: 660: 99.59
+	Mm
		663032 GRIA1_MOUSE (14-913): 0: 747: 37.15		DLG4_MOUSE (1-724): 0: 660: 99.59
+	Hs
		838524 GRIA3_HUMAN (1-904): 0: 739: 36.21		DLG4_HUMAN (1-724): 0: 660: 100.00
+	Mm
		1223788 GRIA3_MOUSE (7-904): 0: 730: 36.33		DLG4_MOUSE (1-724): 0: 660: 99.59
+	Hs
		838486 GRIA2_HUMAN (1-904): 0: 721: 35.67		DLG4_HUMAN (1-724): 0: 660: 100.00
+	Mm
		663107 GRIA2_MOUSE (1-904): 0: 718: 35.78		DLG4_MOUSE (1-724): 0: 660: 99.59
+	Hs
		1006072 GRIK5_HUMAN (19-889): 0: 682: 41.80		DLG4_HUMAN (1-724): 0: 660: 100.00
+	Mm
		1223174 GRIK5_MOUSE (19-889): 0: 680: 41.57		DLG4_MOUSE (1-724): 0: 660: 99.59
+	Mm
		663021 GRIA1_MOUSE (14-913): 0: 747: 37.15		DLG3_MOUSE (8-724): 0: 584: 62.67
+	Hs
		838451 GRIA1_HUMAN (14-913): 0: 756: 37.41		DLG1_HUMAN (32-724): 0: 572: 73.33
+	Rn
		623661 GRIA1_RAT (14-913): 0: 749: 37.15		DLG1_RAT (6-724): 0: 562: 67.95
+	Hs
		1157441 GRIK5_HUMAN (19-889): 0: 682: 41.80		DLG3_HUMAN (28-724): 0: 593: 64.92
+	Mm
		663045 GRIA1_MOUSE (14-913): 0: 747: 37.15		DLG2_MOUSE (227-572): 1.84e-17: 89: 17.60
+	Rn
		623697 GRIA2_RAT (1-904): 0: 719: 35.78		MPP4_RAT (64-236): 2.37e-16: 84: 15.14