HitPredict

Interactor 1: ARP3 (P47117)
Actin-related protein 3 (Actin-like protein ARP3) (Actin-like protein 3)
Gene: ARP3

Interactor 2: ARPC3 (Q05933)
Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC)
Gene: ARC18

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.963

Property	Details
Experiments	9210376, 11805826, 16183906, 16554755, 16429126, 37968396, 10377407
Identification Methods	biochemical, tandem affinity purification, affinity chromatography technology, chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~P21-Arc
Common GO terms	GO:0005885 - Arp2/3 protein complex GO:0015629 - actin cytoskeleton GO:0034314 - Arp2/3 complex-mediated actin nucleation GO:0045010 - actin nucleation GO:0044396 - actin cortical patch organization and 1 others more... GO:0051015 - actin filament binding
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 449 Sc			1 178
+	Sp
		689652 ARP3_SCHPO (1-446): 0: 606: 68.01		ARPC3_SCHPO (1-178): 2.32e-89: 260: 53.63
+	Hs
		169059 ACTB_HUMAN (1-444): 0: 520: 32.44		ARPC3_HUMAN (1-178): 4.24e-97: 280: 46.07
+	Hs
		169069 ACTG_HUMAN (3-444): 0: 520: 32.36		ARPC3_HUMAN (1-178): 4.24e-97: 280: 46.07
+	Hs
		169070 ACTC_HUMAN (2-444): 0: 515: 32.29		ARPC3_HUMAN (1-178): 4.24e-97: 280: 46.07
+	Hs
		169141 ARP3B_HUMAN (7-449): 2.34e-173: 494: 57.46		ARPC3_HUMAN (1-178): 4.24e-97: 280: 46.07
+	Hs
		169061 ARP3_HUMAN (7-449): 6.34e-172: 490: 58.35		ARPC3_HUMAN (1-178): 4.24e-97: 280: 46.07