HitPredict

Interactor 1: ZO1 (P39447)
Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1)
Gene: Tjp1

Interactor 2: KCNQ2 (Q9Z351)
Potassium voltage-gated channel subfamily KQT member 2 (KQT-like 2) (Potassium channel subunit alpha KvLQT2) (Voltage-gated potassium channel subunit Kv7.2)
Gene: KCNQ2

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36417873
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005516 - calmodulin binding GO:0005886 - plasma membrane GO:0007605 - sensory perception of sound GO:0009986 - cell surface
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1745 Mm			1 759
+	Hs
		254990 ZO1_HUMAN (1-1745): 0: 1015: 90.79		HCN1_HUMAN (36-757): 1.99e-90: 304: 10.67
+	Hs
		168634 CSKP_HUMAN (217-804): 8.93e-89: 313: 14.10		KCNA4_HUMAN (76-342): 3.91e-92: 303: 21.87
+	Hs
		648777 MPP7_HUMAN (290-805): 3.07e-84: 290: 14.72		KCNA4_HUMAN (76-342): 3.91e-92: 303: 21.87
+	Hs
		642917 MPP7_HUMAN (290-805): 3.07e-84: 290: 14.72		KCNA3_HUMAN (38-398): 2.74e-86: 285: 18.36
+	Rn
		583947 DLG3_RAT (16-400): 2.41e-45: 180: 15.70		KCNA4_RAT (76-342): 3.98e-92: 303: 21.87
+	Hs
		254959 DLG4_HUMAN (1-111): 8.72e-27: 120: 30.17		HCN1_HUMAN (36-757): 1.99e-90: 304: 10.67
+	Rn
		583946 DLG4_RAT (1-111): 6.32e-27: 121: 30.17		KCNA4_RAT (76-342): 3.98e-92: 303: 21.87
+	Mm
		1222743 DLG4_MOUSE (1-111): 8.06e-27: 120: 30.17		KCNA4_MOUSE (76-342): 4.01e-92: 303: 21.87
+	Hs
		648766 DLG4_HUMAN (1-111): 8.72e-27: 120: 30.17		KCNA4_HUMAN (76-342): 3.91e-92: 303: 21.87
+	Hs
		648813 DLG4_HUMAN (1-111): 8.72e-27: 120: 30.17		KCNA5_HUMAN (45-335): 3.32e-92: 302: 19.25
+	Hs
		1006112 DLG4_HUMAN (1-111): 8.72e-27: 120: 30.17		KCND2_HUMAN (19-511): 6.96e-91: 299: 16.73
+	Hs
		648769 DLG1_HUMAN (1-112): 3.28e-25: 116: 31.58		KCNA4_HUMAN (76-342): 3.91e-92: 303: 21.87
+	Mm
		990946 DLG4_MOUSE (1-111): 8.06e-27: 120: 30.17		KCNA2_MOUSE (38-384): 1.51e-91: 297: 17.62
+	Hs
		595035 DLG4_HUMAN (1-111): 8.72e-27: 120: 30.17		KCNA2_HUMAN (38-384): 1.57e-90: 294: 17.62
+	Mm
		595204 DLG4_MOUSE (1-111): 8.06e-27: 120: 30.17		KCNA3_MOUSE (38-398): 6.19e-90: 293: 18.36
+	Hs
		1006055 DLG4_HUMAN (1-111): 8.72e-27: 120: 30.17		KCNA1_HUMAN (38-384): 7.39e-89: 290: 17.94
+	Mm
		595024 DLG4_MOUSE (1-111): 8.06e-27: 120: 30.17		KCNA1_MOUSE (38-384): 1.37e-88: 289: 17.94
+	Hs
		642796 DLG4_HUMAN (1-111): 8.72e-27: 120: 30.17		KCNA3_HUMAN (38-398): 2.74e-86: 285: 18.36
+	Hs
		642835 DLG1_HUMAN (1-112): 3.28e-25: 116: 31.58		KCNA3_HUMAN (38-398): 2.74e-86: 285: 18.36
+	Mm
		1223402 DLG4_MOUSE (1-111): 8.06e-27: 120: 30.17		KCNA6_MOUSE (126-316): 9.65e-17: 85.9: 27.89