HitPredict

Interactor 1: SOX2 (P48431)
Transcription factor SOX-2
Gene: SOX2

Interactor 2: I2BP1 (Q8IU81)
Interferon regulatory factor 2-binding protein 1 (IRF-2-binding protein 1) (IRF-2BP1) (Probable E3 ubiquitin-protein ligase IRF2BP1) (EC 2.3.2.27) (Probable RING-type E3 ubiquitin transferase IRF2BP1)
Gene: IRF2BP1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	23667531
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 317 Hs			1 584
+	Hs
		1215907 CIC_HUMAN (3-272): 8.9e-33: 130: 22.26		I2BP1_HUMAN (1-584): 0: 879: 100.00
+	Hs
		727891 SOX6_HUMAN (29-244): 2.42e-29: 120: 23.61		I2BP1_HUMAN (1-584): 0: 879: 100.00
+	Hs
		818196 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		I2BP2_HUMAN (7-263): 1.14e-62: 218: 29.94
+	Hs
		1191149 HM20A_HUMAN (6-248): 2.71e-37: 137: 15.32		I2BP2_HUMAN (7-263): 1.14e-62: 218: 29.94
+	Hs
		727885 SOX6_HUMAN (29-244): 2.42e-29: 120: 23.61		I2BP2_HUMAN (7-263): 1.14e-62: 218: 29.94
+	Hs
		727802 SOX5_HUMAN (2-127): 7.91e-43: 158: 41.27		I2BPL_HUMAN (2-84): 3.89e-28: 121: 65.48
+	Ce
		70274 EGL13_CAEEL (8-178): 7.66e-34: 130: 35.09		B2D6P5_CAEEL (9-100): 1.35e-34: 137: 40.78
+	Ce
		954973 EGL13_CAEEL (8-178): 7.66e-34: 130: 35.09		P92004_CAEEL (9-100): 1.53e-34: 137: 40.78
+	Hs
		727922 SOX6_HUMAN (29-244): 2.42e-29: 120: 23.61		I2BPL_HUMAN (2-84): 3.89e-28: 121: 65.48