HitPredict

Interactor 1: PRS4 (P48601)
26S proteasome regulatory subunit 4 (P26s4)
Gene: Rpt2

Interactor 2: Q9VK14 (Q9VK14)
Proteasome subunit alpha type
Gene: Prosalpha6T

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	19079254
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AAA~Proteasome, AAA~Proteasome_A_N, AAA_lid_3~Proteasome, AAA_lid_3~Proteasome_A_N
Common GO terms	GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 439 Dm			1 289
+	Hs
		637380 PRS4_HUMAN (24-439): 8.92e-138: 404: 92.55		PSA1_HUMAN (1-262): 7.51e-107: 312: 50.19
+	Sc
		771342 PRS10_YEAST (9-436): 8.69e-144: 419: 37.82		PSA6_YEAST (1-232): 2.68e-100: 294: 46.58
+	Dm
		522484 PRS4_DROME (1-439): 7.01e-141: 411: 100.00		PSA1_DROME (1-237): 1.09e-97: 290: 63.90
+	Hs
		637667 PRS4_HUMAN (24-439): 8.92e-138: 404: 92.55		PSA2_HUMAN (1-236): 2.12e-101: 297: 29.41
+	At
		188706 PRS4A_ARATH (1-439): 4.1e-137: 402: 77.43		PSA1B_ARATH (1-236): 2.94e-97: 289: 50.00
+	At
		709290 PRS4A_ARATH (1-439): 4.1e-137: 402: 77.43		PSA1A_ARATH (1-236): 1.19e-97: 289: 50.85
+	Dm
		820495 PRS4_DROME (1-439): 7.01e-141: 411: 100.00		PSA5_DROME (1-236): 3.53e-94: 279: 28.57
+	Hs
		156269 PRS4_HUMAN (24-439): 8.92e-138: 404: 92.55		PSA7_HUMAN (6-233): 9.24e-96: 284: 35.93
+	At
		286460 PRS4A_ARATH (1-439): 4.1e-137: 402: 77.43		PSA5A_ARATH (1-235): 1.14e-95: 283: 31.67
+	Hs
		656193 PRS4_HUMAN (24-439): 8.92e-138: 404: 92.55		PSA5_HUMAN (1-235): 9.39e-95: 281: 29.34
+	At
		1114627 PRS4A_ARATH (1-439): 4.1e-137: 402: 77.43		PSA5B_ARATH (1-235): 4.97e-95: 281: 31.67
+	Hs
		638104 PRS4_HUMAN (24-439): 8.92e-138: 404: 92.55		PSA4_HUMAN (1-232): 6.37e-94: 279: 28.87
+	Hs
		893639 PRS4_HUMAN (24-439): 8.92e-138: 404: 92.55		PSA6_HUMAN (1-239): 4.74e-94: 279: 28.34
+	At
		286458 PRS4A_ARATH (1-439): 4.1e-137: 402: 77.43		PSA4A_ARATH (1-244): 2.5e-94: 280: 29.37
+	At
		188699 PRS4A_ARATH (1-439): 4.1e-137: 402: 77.43		PSA2A_ARATH (1-236): 2.84e-93: 277: 31.93
+	At
		286451 PRS4A_ARATH (1-439): 4.1e-137: 402: 77.43		PSA6A_ARATH (1-239): 9.03e-93: 276: 31.58
+	At
		1225875 PRS4A_ARATH (1-439): 4.1e-137: 402: 77.43		PSA2B_ARATH (1-236): 2.78e-92: 274: 31.93
+	Sc
		619375 PRS10_YEAST (9-436): 8.69e-144: 419: 37.82		PSA3_YEAST (1-227): 1.62e-32: 122: 32.63
+	At
		189237 PRS4A_ARATH (1-439): 4.1e-137: 402: 77.43		PSA7B_ARATH (5-195): 1.17e-33: 124: 38.38
+	At
		672533 PRS4A_ARATH (1-439): 4.1e-137: 402: 77.43		PSA7A_ARATH (5-195): 3.28e-33: 123: 37.88