Interactor 1: KC1A (P48729)
Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1)
Gene: CSNK1A1

Interactor 2: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.77 0.60 0.683

The method score is based on:

Property Details
Experiments 32901886, 19759023, 22916255, 20708156
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0032436 - positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions 5

Homologous interactions

Color coding for hit scores

1 337
Hs

1 491
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024