HitPredict

Interactor 1: AMPH (P49418)
Amphiphysin
Gene: AMPH

Interactor 2: AP1B1 (Q10567)
AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit)
Gene: AP1B1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.670

Property	Details
Experiments	9280305, 28514442, 33961781
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 695 Hs			1 949
+	Hs
		827733 AMPH_HUMAN (1-695): 5.58e-133: 409: 100.00		AP2B1_HUMAN (1-949): 0: 944: 81.45
+	Mm
		1186720 AMPH_MOUSE (1-695): 5.33e-119: 373: 82.90		AP2B1_MOUSE (1-949): 0: 944: 81.35
+	Rn
		139975 AMPH_RAT (1-695): 6.91e-115: 362: 84.75		AP2B1_RAT (1-949): 0: 944: 81.45
+	Hs
		203223 SYNJ1_HUMAN (187-647): 1.83e-28: 124: 11.70		AP1B1_HUMAN (1-949): 0: 978: 100.00
+	Mm
		101412 F8VPR5_MOUSE (107-618): 2.01e-32: 137: 13.51		AP1B1_MOUSE (1-949): 0: 950: 95.89
+	Hs
		321511 AMPH_HUMAN (1-695): 5.58e-133: 409: 100.00		AP2A1_HUMAN (12-943): 0: 677: 18.58
+	Rn
		139988 BIN1_RAT (372-695): 8.26e-34: 139: 23.15		AP2B1_RAT (1-949): 0: 944: 81.45
+	Hs
		203219 SYNJ1_HUMAN (187-647): 1.83e-28: 124: 11.70		AP2B1_HUMAN (1-949): 0: 944: 81.45
+	Hs
		1014106 CABIN_HUMAN (291-589): 2.25e-12: 72.8: 12.87		AP1B1_HUMAN (1-949): 0: 978: 100.00
+	Hs
		302118 AMPH_HUMAN (1-695): 5.58e-133: 409: 100.00		AP2A2_HUMAN (12-945): 0: 625: 18.33
+	Rn
		88753 AMPH_RAT (1-695): 6.91e-115: 362: 84.75		D3ZUY8_RAT (12-943): 0: 670: 18.03
+	Mm
		567528 AMPH_MOUSE (1-695): 5.33e-119: 373: 82.90		AP2A2_MOUSE (12-945): 0: 634: 17.94
+	Rn
		139980 AMPH_RAT (1-695): 6.91e-115: 362: 84.75		Q66HM2_RAT (12-945): 0: 631: 17.92
+	Hs
		212606 AMPH_HUMAN (1-695): 5.58e-133: 409: 100.00		AP1G1_HUMAN (12-822): 0: 556: 17.29
+	Hs
		131189 BIN1_HUMAN (375-694): 1.37e-32: 135: 23.44		AP2A1_HUMAN (12-943): 0: 677: 18.58
+	Rn
		88754 BIN1_RAT (372-695): 8.26e-34: 139: 23.15		D3ZUY8_RAT (12-943): 0: 670: 18.03
+	Hs
		203194 SYNJ1_HUMAN (187-647): 1.83e-28: 124: 11.70		AP2A1_HUMAN (12-943): 0: 677: 18.58
+	Rn
		139993 BIN1_RAT (372-695): 8.26e-34: 139: 23.15		Q66HM2_RAT (12-945): 0: 631: 17.92
+	Hs
		131185 BIN1_HUMAN (375-694): 1.37e-32: 135: 23.44		AP2A2_HUMAN (12-945): 0: 625: 18.33
+	Rn
		1144064 SYNJ1_RAT (186-667): 1.94e-25: 114: 13.82		Q66HM2_RAT (12-945): 0: 631: 17.92