Protein: STAT6
Signal transducer and activator of transcription 6 (IL-4 Stat)

Gene: STAT6
Organism: Homo sapiens
Interactions: 63
UniProt ID: P42226

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

838238

NCOA1
Nuclear receptor coactivator 1

7

10

Small-scale

0.968

High

838235

IRF4
Interferon regulatory factor 4

3

20

Small-scale

0.875

High

838223

STAT2
Signal transducer and activator of transcription 2

2

16

Small-scale

0.776

High

607543

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

17

Small-scale

0.747

High

665032

IL4RA
Interleukin-4 receptor subunit alpha

5

20

Small-scale

0.710

High

827689

STAT3
Signal transducer and activator of transcription 3

1

16

High-throughput

0.698

High

838252

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

6

High-throughput

0.698

High

187308

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

1

High-throughput

0.691

High

838220

STAT6
Signal transducer and activator of transcription 6

1

16

Small-scale

0.665

High

838222

JAK3
Tyrosine-protein kinase JAK3

1

20

Small-scale

0.665

High

838229

EP300
Histone acetyltransferase p300

3

13

Small-scale

0.656

High

658650

JAK1
Tyrosine-protein kinase JAK1

1

20

Small-scale

0.647

High

838236

NCOA2
Nuclear receptor coactivator 2

1

8

Small-scale

0.647

High

838247

CBP
CREB-binding protein

3

14

Small-scale

0.646

High

838241

SND1
Staphylococcal nuclease domain-containing protein 1

2

0

Small-scale

0.619

High

838226

IRF9
Interferon regulatory factor 9

1

20

Small-scale

0.618

High

838262

NCOA3
Nuclear receptor coactivator 3

1

8

Small-scale

0.618

High

838261

TRAF6
TNF receptor-associated factor 6

2

7

Small-scale

0.584

High

838231

NMI
N-myc-interactor

2

6

Small-scale

0.576

High

456647

ANXA2
Annexin A2

1

1

Small-scale

0.573

High

838249

LITAF
Lipopolysaccharide-induced tumor necrosis factor-alpha factor

1

1

Small-scale

0.573

High

838257

TBK1
Serine/threonine-protein kinase TBK1

1

3

Small-scale

0.568

High

626113

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

10

Small-scale

0.561

High

655098

SFPQ
Splicing factor, proline- and glutamine-rich

1

1

Small-scale

0.561

High

789421

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

Small-scale

0.561

High

838243

STING
Stimulator of interferon genes protein

1

4

Small-scale

0.554

High

446106

FCER2
Low affinity immunoglobulin epsilon Fc receptor

2

1

Small-scale

0.549

High

180739

TIF1A
Transcription intermediary factor 1-alpha

1

20

High-throughput

0.541

High

838224

PKNX1
Homeobox protein PKNOX1

1

1

High-throughput

0.541

High

838244

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

1

High-throughput

0.541

High

838251

ZN407
Zinc finger protein 407

1

1

High-throughput

0.541

High

838255

RNF12
E3 ubiquitin-protein ligase RLIM

1

2

High-throughput

0.541

High

838232

KIF22
Kinesin-like protein KIF22

1

1

High-throughput

0.536

High

838227

CEBPZ
CCAAT/enhancer-binding protein zeta

1

0

High-throughput

0.518

High

838228

ZNF92
Zinc finger protein 92

1

0

High-throughput

0.518

High

838233

DAZP2
DAZ-associated protein 2

1

0

High-throughput

0.518

High

838253

ANKZ1
tRNA endonuclease ANKZF1

1

0

High-throughput

0.518

High

602879

INAR1
Interferon alpha/beta receptor 1

1

15

Small-scale

0.515

High

838234

PLEC
Plectin

1

4

High-throughput

0.515

High

838239

PAR14
Protein mono-ADP-ribosyltransferase PARP14

1

7

Small-scale

0.515

High

838254

FKRP
Ribitol 5-phosphate transferase FKRP

1

0

High-throughput

0.513

High

838256

POLK
DNA polymerase kappa

1

0

High-throughput

0.513

High

378420

IFNG
Interferon gamma

1

3

Small-scale

0.501

High

590985

LOX15
Polyunsaturated fatty acid lipoxygenase ALOX15

1

0

Small-scale

0.493

High

838242

MAVS
Mitochondrial antiviral-signaling protein

1

3

Small-scale

0.484

High

413346

P53
Cellular tumor antigen p53

1

3

Small-scale

0.481

High

838237

CEBPE
CCAAT/enhancer-binding protein epsilon

1

9

Small-scale

0.481

High

838260

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

289126

PRDM1
PR domain zinc finger protein 1

1

1

Small-scale

0.479

High

429463

JUN
Transcription factor Jun

1

12

Small-scale

0.479

High

533895

IRF1
Interferon regulatory factor 1

1

20

Small-scale

0.479

High

838230

TIF1B
Transcription intermediary factor 1-beta

1

11

Small-scale

0.479

High

838240

NB5R2
NADH-cytochrome b5 reductase 2

1

4

High-throughput

0.479

High

838245

BICD2
Protein bicaudal D homolog 2

1

5

Small-scale

0.479

High

838258

UBP18
Ubl carboxyl-terminal hydrolase 18

1

7

Small-scale

0.479

High

838225

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.460

High

838248

RCN3
Reticulocalbin-3

1

1

High-throughput

0.439

High

838246

AP2C
Transcription factor AP-2 gamma

1

0

High-throughput

0.438

High

379455

IGHG4
Immunoglobulin heavy constant gamma 4

1

2

Small-scale

0.437

High

838221

CCL11
Eotaxin

1

5

Small-scale

0.437

High

838259

CCL26
C-C motif chemokine 26

1

5

Small-scale

0.437

High

838250

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

0

Small-scale

0.251

Low


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Last updated: 11Aug2025