Protein: BCL3
B-cell lymphoma 3 protein (BCL-3) (Proto-oncogene BCL3)

Gene: BCL3
Organism: Homo sapiens
Interactions: 50
UniProt ID: P20749

Gene Ontology (top 5):
GO:0002268 - follicular dendritic cell differentiation
GO:0002315 - marginal zone B cell differentiation
GO:0002455 - humoral immune response mediated by circulating immunoglobulin
GO:0002467 - germinal center formation
GO:0003713 - transcription coactivator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

626062

NFKB1
Nuclear factor NF-kappa-B p105 subunit

10

20

Small-scale

0.975

High

634918

NFKB2
Nuclear factor NF-kappa-B p100 subunit

7

19

Small-scale

0.959

High

440357

FYN
Tyrosine-protein kinase Fyn

2

14

Small-scale

0.768

High

634914

GSK3B
Glycogen synthase kinase-3 beta

1

16

Small-scale

0.724

High

177170

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

17

High-throughput

0.698

High

439944

LCK
Tyrosine-protein kinase Lck

1

14

Small-scale

0.690

High

634931

BARD1
BRCA1-associated RING domain protein 1

1

18

Small-scale

0.680

High

177793

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

20

Small-scale

0.647

High

634908

MK01
Mitogen-activated protein kinase 1

1

7

Small-scale

0.647

High

634909

AKT1
RAC-alpha serine/threonine-protein kinase

1

13

Small-scale

0.647

High

142177

PIR
Pirin

2

1

Small-scale

0.636

High

634916

CTBP2
C-terminal-binding protein 2

2

11

Small-scale

0.631

High

634930

KAT5
Histone acetyltransferase KAT5

2

3

Small-scale

0.631

High

634920

CTBP1
C-terminal-binding protein 1

2

11

Small-scale

0.624

High

634911

CTNB1
Catenin beta-1

1

12

Small-scale

0.618

High

634922

CUL4A
Cullin-4A

1

20

High-throughput

0.618

High

634927

FBXW8
F-box/WD repeat-containing protein 8

1

20

Small-scale

0.618

High

634935

HDAC6
Protein deacetylase HDAC6

1

20

Small-scale

0.618

High

188172

HDAC3
Histone deacetylase 3

2

20

Small-scale

0.584

High

634921

HDAC1
Histone deacetylase 1

2

20

Small-scale

0.584

High

634934

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

2

3

Small-scale

0.584

High

634937

RUVB2
RuvB-like 2

2

10

Small-scale

0.584

High

429294

JUN
Transcription factor Jun

1

14

Small-scale

0.573

High

634929

CSN5
COP9 signalosome complex subunit 5

1

6

Small-scale

0.573

High

353843

BCL10
B-cell lymphoma/leukemia 10

1

1

Small-scale

0.546

High

600732

HSP76
Heat shock 70 kDa protein 6

1

20

High-throughput

0.536

High

634928

HS105
Heat shock protein 105 kDa

1

20

High-throughput

0.536

High

370559

FOS
Protein c-Fos

1

19

Small-scale

0.527

High

625760

RXRA
Retinoic acid receptor RXR-alpha

1

20

Small-scale

0.527

High

634919

EP300
Histone acetyltransferase p300

1

15

Small-scale

0.527

High

634924

NCOA1
Nuclear receptor coactivator 1

1

9

Small-scale

0.527

High

634926

N4BP2
NEDD4-binding protein 2

1

4

Small-scale

0.527

High

628695

TBP
TATA-box-binding protein

1

2

Small-scale

0.501

High

634917

TF2B
Transcription initiation factor IIB

1

1

Small-scale

0.501

High

634923

MARE1
Microtubule-associated protein RP/EB family member 1

1

1

Small-scale

0.481

High

634939

TRAF6
TNF receptor-associated factor 6

1

19

Small-scale

0.481

High

634915

TF2AA
Transcription initiation factor IIA subunit 1

1

0

Small-scale

0.480

High

222714

PRC1
Protein regulator of cytokinesis 1

1

7

High-throughput

0.479

High

246429

KDM1A
Lysine-specific histone demethylase 1A

1

8

Small-scale

0.479

High

346848

BAG2
BAG family molecular chaperone regulator 2

1

7

Small-scale

0.479

High

395483

ESR1
Estrogen receptor

1

20

Small-scale

0.479

High

633593

PSB1
Proteasome subunit beta type-1

1

10

Small-scale

0.479

High

634910

HSP74
Heat shock 70 kDa protein 4

1

20

Small-scale

0.479

High

634912

STAT3
Signal transducer and activator of transcription 3

1

8

Small-scale

0.479

High

634913

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

8

Small-scale

0.479

High

634925

RN123
E3 ubiquitin-protein ligase RNF123

1

8

High-throughput

0.479

High

634933

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

1

11

Small-scale

0.479

High

634936

RCOR1
REST corepressor 1

1

19

Small-scale

0.479

High

634938

RUVB1
RuvB-like 1

1

10

Small-scale

0.479

High

634932

NUP58
Nucleoporin p58/p45

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025