HitPredict

Interactor 1: CLK2 (P49760)
Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2)
Gene: CLK2

Interactor 2: SRSF3 (P84103)
Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3)
Gene: SRSF3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.858

Property	Details
Experiments	32296183, 33961781, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, two hybrid array, validated two hybrid, two hybrid prey pooling approach, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005654 - nucleoplasm GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 499 Hs			1 164
+	Hs
		833887 CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00		SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35
+	Hs
		833742 CLK1_HUMAN (1-484): 3.66e-144: 424: 53.31		SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35
+	Hs
		833870 CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00		SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65
+	Hs
		266941 CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00		SRS10_HUMAN (1-164): 2.25e-24: 96.6: 32.54
+	Hs
		833711 CLK1_HUMAN (1-484): 3.66e-144: 424: 53.31		SRSF3_HUMAN (1-164): 6.39e-27: 100: 100.00
+	Hs
		833720 CLK1_HUMAN (1-484): 3.66e-144: 424: 53.31		SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65
+	Hs
		516416 CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00		PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77
+	Hs
		833727 CLK1_HUMAN (1-484): 3.66e-144: 424: 53.31		SRSF5_HUMAN (10-112): 2.09e-24: 97: 44.34
+	Hs
		266940 CLK1_HUMAN (1-484): 3.66e-144: 424: 53.31		SRS10_HUMAN (1-164): 2.25e-24: 96.6: 32.54
+	Hs
		834022 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		SRSF3_HUMAN (1-164): 6.39e-27: 100: 100.00
+	Hs
		834026 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65
+	Hs
		833871 CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00		SRSF4_HUMAN (11-112): 3.43e-16: 76.6: 39.22
+	Hs
		833875 CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00		SRSF6_HUMAN (11-88): 3.86e-16: 75.8: 47.44
+	Hs
		834031 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		SRSF5_HUMAN (10-112): 2.09e-24: 97: 44.34
+	Hs
		266942 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		SRS10_HUMAN (1-164): 2.25e-24: 96.6: 32.54
+	Hs
		833721 CLK1_HUMAN (1-484): 3.66e-144: 424: 53.31		SRSF4_HUMAN (11-112): 3.43e-16: 76.6: 39.22
+	Hs
		833728 CLK1_HUMAN (1-484): 3.66e-144: 424: 53.31		SRSF6_HUMAN (11-88): 3.86e-16: 75.8: 47.44
+	Hs
		516417 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77
+	Hs
		834027 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		SRSF4_HUMAN (11-112): 3.43e-16: 76.6: 39.22
+	Hs
		834032 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		SRSF6_HUMAN (11-88): 3.86e-16: 75.8: 47.44