HitPredict

Interactor 1: STAT3 (P42227)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Interactor 2: Q99K94 (Q99K94)
Signal transducer and activator of transcription
Gene: Stat1

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	20211142
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	SH2~SH2, SH2~STAT_linker, STAT_alpha~STAT_bind, STAT_alpha~STAT_int, STAT_alpha~STAT_linker, STAT_bind~STAT_bind, STAT_bind~STAT_linker, STAT_int~STAT_int, STAT_linker~STAT_linker
Common GO terms	GO:0003677 - DNA binding GO:0003700 - DNA-binding transcription factor activity GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0019221 - cytokine-mediated signaling pathway
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 770 Mm			1 712
+	Hs
		827688 STAT3_HUMAN (1-770): 0: 1047: 99.87		STAT1_HUMAN (1-712): 0: 932: 93.68
+	Mm
		838263 STAT3_MOUSE (1-770): 0: 1050: 100.00		STAT3_MOUSE (1-710): 0: 859: 53.70
+	Hs
		827684 STAT3_HUMAN (1-770): 0: 1047: 99.87		STAT3_HUMAN (1-710): 0: 858: 53.70
+	Hs
		827785 STAT3_HUMAN (1-770): 0: 1047: 99.87		STAT4_HUMAN (1-712): 0: 831: 54.41
+	Mm
		1408775 Q99K94_MOUSE (1-715): 0: 910: 53.62		Q99K94_MOUSE (1-712): 0: 964: 100.00
+	Hs
		838008 STAT1_HUMAN (1-749): 0: 929: 51.52		STAT1_HUMAN (1-712): 0: 932: 93.68
+	Hs
		827716 STAT3_HUMAN (1-770): 0: 1047: 99.87		STAT2_HUMAN (1-710): 0: 765: 43.93
+	Mm
		838334 STAT3_MOUSE (1-770): 0: 1050: 100.00		Q9QXJ2_MOUSE (1-710): 0: 760: 42.04
+	Hs
		827710 STAT3_HUMAN (1-770): 0: 1047: 99.87		STA5B_HUMAN (1-710): 0: 747: 30.47
+	Hs
		827690 STAT3_HUMAN (1-770): 0: 1047: 99.87		STA5A_HUMAN (1-710): 0: 736: 29.70
+	Hs
		838097 STAT1_HUMAN (1-749): 0: 929: 51.52		STAT4_HUMAN (1-712): 0: 831: 54.41
+	Mm
		838209 STAT1_MOUSE (1-749): 0: 915: 51.32		STAT4_MOUSE (1-712): 0: 811: 53.71
+	Hs
		1132020 STAT4_HUMAN (1-729): 0: 893: 48.44		STAT4_HUMAN (1-712): 0: 831: 54.41
+	Hs
		838030 STAT1_HUMAN (1-749): 0: 929: 51.52		STAT2_HUMAN (1-710): 0: 765: 43.93
+	Hs
		838027 STAT1_HUMAN (1-749): 0: 929: 51.52		STA5B_HUMAN (1-710): 0: 747: 30.47
+	Hs
		827689 STAT3_HUMAN (1-770): 0: 1047: 99.87		STAT6_HUMAN (1-711): 0: 627: 25.75
+	Hs
		838009 STAT1_HUMAN (1-749): 0: 929: 51.52		STA5A_HUMAN (1-710): 0: 736: 29.70