HitPredict

Interactor 1: MMP14 (P50281)
Matrix metalloproteinase-14 (MMP-14) (EC 3.4.24.80) (MMP-X1) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP)
Gene: MMP14

Interactor 2: TIMP4 (Q99727)
Metalloproteinase inhibitor 4 (Tissue inhibitor of metalloproteinases 4) (TIMP-4)
Gene: TIMP4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.812

Property	Details
Experiments	31677819, 12475252
Identification Methods	affinity chromatography technology, surface plasmon resonance, enzymatic study
Interaction Type	physical association, direct interaction, enzymatic reaction

Property	Details
Interacting Pfam domains	Hemopexin~TIMP, Peptidase_M10~TIMP
Common GO terms	GO:0005615 - extracellular space GO:0031012 - extracellular matrix
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 582 Hs			1 224
+	Hs
		554808 MMP14_HUMAN (1-582): 0: 768: 100.00		TIMP2_HUMAN (27-224): 2.73e-102: 297: 49.75
+	Hs
		554810 MMP16_HUMAN (33-582): 0: 759: 55.46		TIMP2_HUMAN (27-224): 2.73e-102: 297: 49.75
+	Hs
		726505 MMP14_HUMAN (1-582): 0: 768: 100.00		TIMP3_HUMAN (15-224): 7.8e-99: 287: 47.66
+	Hs
		344795 MMP14_HUMAN (1-582): 0: 768: 100.00		TIMP1_HUMAN (7-207): 1.87e-86: 256: 36.10
+	Hs
		554809 MMP15_HUMAN (27-582): 0: 685: 52.48		TIMP2_HUMAN (27-224): 2.73e-102: 297: 49.75
+	Hs
		439275 MMP3_HUMAN (11-508): 0: 580: 35.77		TIMP4_HUMAN (1-224): 1.36e-121: 345: 100.00
+	Hs
		372742 MMP1_HUMAN (16-508): 0: 567: 35.34		TIMP4_HUMAN (1-224): 1.36e-121: 345: 100.00
+	Hs
		439263 MMP3_HUMAN (11-508): 0: 580: 35.77		TIMP2_HUMAN (27-224): 2.73e-102: 297: 49.75
+	Hs
		439265 MMP3_HUMAN (11-508): 0: 580: 35.77		TIMP3_HUMAN (15-224): 7.8e-99: 287: 47.66
+	Hs
		372726 MMP1_HUMAN (16-508): 0: 567: 35.34		TIMP2_HUMAN (27-224): 2.73e-102: 297: 49.75
+	Mm
		706099 MMP13_MOUSE (10-504): 0: 561: 32.81		TIMP3_MOUSE (15-224): 1.31e-94: 277: 47.66
+	Hs
		344781 MMP3_HUMAN (11-508): 0: 580: 35.77		TIMP1_HUMAN (7-207): 1.87e-86: 256: 36.10
+	Hs
		344777 MMP1_HUMAN (16-508): 0: 567: 35.34		TIMP1_HUMAN (7-207): 1.87e-86: 256: 36.10
+	Hs
		344784 MMP10_HUMAN (11-508): 0: 565: 35.32		TIMP1_HUMAN (7-207): 1.87e-86: 256: 36.10
+	Hs
		439254 MMP2_HUMAN (4-226): 4.4e-79: 264: 34.78		TIMP4_HUMAN (1-224): 1.36e-121: 345: 100.00
+	Hs
		439223 MMP2_HUMAN (4-226): 4.4e-79: 264: 34.78		TIMP2_HUMAN (27-224): 2.73e-102: 297: 49.75
+	Hs
		439230 MMP2_HUMAN (4-226): 4.4e-79: 264: 34.78		TIMP3_HUMAN (15-224): 7.8e-99: 287: 47.66
+	Hs
		540409 MMP9_HUMAN (4-224): 6.56e-65: 227: 36.20		TIMP2_HUMAN (27-224): 2.73e-102: 297: 49.75
+	Hs
		344780 MMP2_HUMAN (4-226): 4.4e-79: 264: 34.78		TIMP1_HUMAN (7-207): 1.87e-86: 256: 36.10
+	Hs
		344786 MMP9_HUMAN (4-224): 6.56e-65: 227: 36.20		TIMP1_HUMAN (7-207): 1.87e-86: 256: 36.10