HitPredict

Interactor 1: GDIB (P50395)
Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2)
Gene: GDI2

Interactor 2: RAB21 (Q9UL25)
Ras-related protein Rab-21
Gene: RAB21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	GDI~Ras
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0045202 - synapse GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 445 Hs			1 225
+	Hs
		838616 GDIB_HUMAN (1-445): 0: 722: 100.00		RAB8A_HUMAN (13-221): 7.3e-97: 282: 37.32
+	Hs
		838621 GDIB_HUMAN (1-445): 0: 722: 100.00		RAB14_HUMAN (10-221): 5.83e-96: 280: 33.95
+	Hs
		838673 GDIB_HUMAN (1-445): 0: 722: 100.00		RAB8B_HUMAN (13-221): 5.77e-96: 280: 34.93
+	Hs
		678336 GDIA_HUMAN (1-444): 0: 714: 86.49		RAB8A_HUMAN (13-221): 7.3e-97: 282: 37.32
+	Hs
		838669 GDIB_HUMAN (1-445): 0: 722: 100.00		RAB2B_HUMAN (15-222): 1.97e-87: 259: 32.56
+	Hs
		838625 GDIB_HUMAN (1-445): 0: 722: 100.00		RAB1A_HUMAN (9-222): 6.14e-87: 257: 32.24
+	Hs
		838683 GDIB_HUMAN (1-445): 0: 722: 100.00		RAB1B_HUMAN (12-222): 1.28e-85: 254: 30.81
+	Hs
		838624 GDIB_HUMAN (1-445): 0: 722: 100.00		RB11A_HUMAN (9-224): 6.96e-85: 252: 32.41
+	Hs
		838647 GDIB_HUMAN (1-445): 0: 722: 100.00		RB11B_HUMAN (9-224): 1e-84: 252: 32.72
+	Mm
		838709 GDIA_MOUSE (1-444): 0: 717: 87.39		RAB1A_MOUSE (9-222): 6.14e-87: 257: 32.24
+	Hs
		838605 GDIB_HUMAN (1-445): 0: 722: 100.00		RAB5C_HUMAN (1-224): 1.01e-51: 168: 39.82
+	Hs
		592161 GDIB_HUMAN (1-445): 0: 722: 100.00		RAB5A_HUMAN (10-224): 2.26e-49: 162: 41.28
+	Hs
		678330 GDIA_HUMAN (1-444): 0: 714: 86.49		RAB5C_HUMAN (1-224): 1.01e-51: 168: 39.82
+	Hs
		838618 GDIB_HUMAN (1-445): 0: 722: 100.00		RAB5B_HUMAN (10-224): 8.75e-47: 155: 38.61
+	Hs
		592123 GDIA_HUMAN (1-444): 0: 714: 86.49		RAB5A_HUMAN (10-224): 2.26e-49: 162: 41.28
+	Hs
		838635 GDIB_HUMAN (1-445): 0: 722: 100.00		RAB31_HUMAN (20-196): 6.55e-46: 152: 44.63
+	Hs
		838699 GDIB_HUMAN (1-445): 0: 722: 100.00		RB22A_HUMAN (20-203): 8.19e-45: 149: 44.62
+	Hs
		678339 GDIA_HUMAN (1-444): 0: 714: 86.49		RAB5B_HUMAN (10-224): 8.75e-47: 155: 38.61
+	Hs
		838608 GDIB_HUMAN (1-445): 0: 722: 100.00		RAB13_HUMAN (20-200): 1.67e-42: 144: 38.67
+	Hs
		678333 GDIA_HUMAN (1-444): 0: 714: 86.49		RAB13_HUMAN (20-200): 1.67e-42: 144: 38.67