HitPredict

Interactor 1: EMD (P50402)
Emerin
Gene: EMD

Interactor 2: SYNE1 (Q8NF91)
Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1)
Gene: SYNE1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	34079125, 12163176, 17462627
Identification Methods	proximity labelling technology, pull down, far western blotting, solid phase assay
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005635 - nuclear envelope GO:0005640 - nuclear outer membrane GO:0005654 - nucleoplasm GO:0005737 - cytoplasm and 2 others more... GO:0016020 - membrane GO:0031965 - nuclear membrane
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 254 Hs			1 8797
+	Hs
		839017 EMD_HUMAN (1-254): 1.32e-153: 429: 100.00		SYNE2_HUMAN (2840-8740): 2.87e-69: 265: 8.94
+	Hs
		839052 EMD_HUMAN (1-254): 1.32e-153: 429: 100.00		CLMN_HUMAN (18-356): 1.22e-62: 238: 46.13
+	Hs
		838821 EMD_HUMAN (1-254): 1.32e-153: 429: 100.00		SPTN1_HUMAN (7955-8728): 7.08e-25: 118: 13.61
+	Hs
		838919 EMD_HUMAN (1-254): 1.32e-153: 429: 100.00		SYNE3_HUMAN (3282-3947): 9.91e-14: 81.3: 19.39