HitPredict

Interactor 1: EPS15 (P42567)
Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)
Gene: EPS15

Interactor 2: DAB2 (P98078)
Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Mitogen-responsive phosphoprotein)
Gene: DAB2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	22648170
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001921 - positive regulation of receptor recycling GO:0005886 - plasma membrane GO:0016324 - apical plasma membrane GO:0030132 - clathrin coat of coated pit GO:0048268 - clathrin coat assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 897 Mm			1 766
+	Hs
		839742 EPS15_HUMAN (1-897): 8.04e-154: 476: 88.65		DAB2_HUMAN (1-766): 9.44e-78: 267: 81.63
+	Hs
		839716 EPS15_HUMAN (1-897): 8.04e-154: 476: 88.65		NUMB_HUMAN (20-678): 7.45e-47: 179: 14.79
+	Mm
		839862 EPS15_MOUSE (1-897): 1.03e-143: 450: 100.00		NUMB_MOUSE (20-678): 3.03e-44: 171: 12.57
+	Mm
		1022123 EP15R_MOUSE (1-894): 2.44e-76: 269: 30.94		DAB2_MOUSE (1-766): 2.91e-93: 309: 100.00
+	Hs
		889351 EP15R_HUMAN (1-849): 2.98e-90: 307: 42.22		NUMB_HUMAN (20-678): 7.45e-47: 179: 14.79
+	Mm
		1022139 ITSN1_MOUSE (2-531): 1.01e-38: 158: 11.89		DAB2_MOUSE (1-766): 2.91e-93: 309: 100.00
+	Mm
		1221956 EP15R_MOUSE (1-894): 2.44e-76: 269: 30.94		ANS1B_MOUSE (2-243): 4.98e-43: 170: 17.89
+	Hs
		1022168 ITSN1_HUMAN (2-523): 5.51e-40: 162: 12.19		DAB2_HUMAN (1-766): 9.44e-78: 267: 81.63
+	Hs
		1022191 REPS1_HUMAN (2-532): 1.57e-34: 143: 12.71		DAB2_HUMAN (1-766): 9.44e-78: 267: 81.63
+	Mm
		1296766 ITSN1_MOUSE (2-531): 1.01e-38: 158: 11.89		ANS1B_MOUSE (2-243): 4.98e-43: 170: 17.89
+	Hs
		889322 REPS1_HUMAN (2-532): 1.57e-34: 143: 12.71		NUMB_HUMAN (20-678): 7.45e-47: 179: 14.79
+	Hs
		286371 ITSN1_HUMAN (2-523): 5.51e-40: 162: 12.19		DAB1_HUMAN (11-633): 9.61e-39: 154: 22.95
+	Hs
		1362037 CTTB2_HUMAN (275-846): 8.06e-41: 165: 15.55		DP13A_HUMAN (20-246): 6.78e-36: 146: 12.66
+	Dm
		118278 M9ND00_DROME (1-444): 3.94e-34: 143: 14.13		NUMB_DROME (24-531): 2.87e-37: 149: 11.91
+	Ce
		1457940 Q9U2T9_CAEEL (2-425): 2.92e-23: 108: 11.01		NUMB1_CAEEL (22-428): 1.54e-48: 183: 13.29
+	Ce
		63405 Q9U2T9_CAEEL (2-425): 2.92e-23: 108: 11.01		A5JYR4_CAEEL (5-390): 1.1e-37: 149: 23.62
+	Ce
		303793 Q9U2T9_CAEEL (2-425): 2.92e-23: 108: 11.01		CED6_CAEEL (1-414): 5.78e-36: 144: 14.75
+	Dm
		95601 E3CTP7_DROME (425-783): 2.24e-12: 73.1: 13.30		NUMB_DROME (24-531): 2.87e-37: 149: 11.91
+	Dm
		597780 Q8T8W3_DROME (239-313): 1.91e-10: 66.2: 44.00		NUMB_DROME (24-531): 2.87e-37: 149: 11.91
+	Ce
		63403 Q8WSP1_CAEEL (218-313): 1.44e-09: 63.9: 40.63		A5JYR4_CAEEL (5-390): 1.1e-37: 149: 23.62