HitPredict

Interactor 1: AFF1 (P51825)
AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4)
Gene: AFF1

Interactor 2: Q8TD98 (Q8TD98)
MLL/AF4 fusion protein
Gene: Q8TD98

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	20153263
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	AF-4~AF-4
Common GO terms	GO:0010468 - regulation of gene expression GO:0032783 - super elongation complex
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 624
+	Hs
		850799 AFF1_HUMAN (1-1210): 3.61e-130: 431: 100.00		AFF1_HUMAN (36-624): 2.64e-47: 181: 76.40
+	Hs
		850828 AFF1_HUMAN (1-1210): 3.61e-130: 431: 100.00		AFF4_HUMAN (30-620): 1.37e-25: 114: 28.84
+	Hs
		850807 AFF1_HUMAN (1-1210): 3.61e-130: 431: 100.00		KMT2A_HUMAN (6-146): 8.61e-25: 112: 90.48
+	Hs
		975340 AFF4_HUMAN (10-1208): 2.3e-90: 318: 34.44		KMT2A_HUMAN (6-146): 8.61e-25: 112: 90.48
+	Hs
		1231747 AN36B_HUMAN (724-1142): 9.59e-52: 201: 14.42		CHAP1_HUMAN (1-393): 1.29e-14: 79.3: 10.43
+	Hs
		975290 Q8TD98_HUMAN (213-831): 1.77e-38: 155: 74.04		KMT2A_HUMAN (6-146): 8.61e-25: 112: 90.48
+	Hs
		1056827 MDC1_HUMAN (161-949): 1.95e-10: 67.6: 10.79		MDC1_HUMAN (5-621): 3.37e-32: 135: 10.71
+	Mm
		1207212 NCOA6_MOUSE (50-1088): 1.15e-11: 71.6: 9.93		KMT2C_MOUSE (9-617): 7.43e-29: 125: 9.48
+	Hs
		152667 KMT2D_HUMAN (357-1098): 8.96e-12: 72.4: 9.13		KMT2C_HUMAN (5-617): 7.19e-28: 122: 11.36
+	Hs
		1057773 NCOA6_HUMAN (66-930): 2.88e-09: 63.9: 8.55		KMT2C_HUMAN (5-617): 7.19e-28: 122: 11.36
+	Hs
		152630 KMT2D_HUMAN (357-1098): 8.96e-12: 72.4: 9.13		KMT2A_HUMAN (6-146): 8.61e-25: 112: 90.48
+	Hs
		152700 KMT2D_HUMAN (357-1098): 8.96e-12: 72.4: 9.13		KMT2B_HUMAN (21-151): 6.29e-24: 109: 39.42
+	Hs
		975251 NCOA6_HUMAN (66-930): 2.88e-09: 63.9: 8.55		KMT2A_HUMAN (6-146): 8.61e-25: 112: 90.48
+	Hs
		1057802 NCOA6_HUMAN (66-930): 2.88e-09: 63.9: 8.55		KMT2B_HUMAN (21-151): 6.29e-24: 109: 39.42
+	Hs
		1056876 MDC1_HUMAN (161-949): 1.95e-10: 67.6: 10.79		MICA3_HUMAN (132-611): 2.69e-21: 101: 11.35
+	Mm
		1351630 PCLO_MOUSE (6-989): 7.06e-16: 85.9: 10.27		PCLO_MOUSE (1-624): 2.86e-11: 69.3: 7.97
+	Hs
		1056937 MDC1_HUMAN (161-949): 1.95e-10: 67.6: 10.79		CHAP1_HUMAN (1-393): 1.29e-14: 79.3: 10.43
+	Hs
		152645 NCOA6_HUMAN (66-930): 2.88e-09: 63.9: 8.55		KMT2D_HUMAN (122-621): 7.88e-09: 61.2: 11.80