HitPredict

Interactor 1: NCBP2 (P52298)
Nuclear cap-binding protein subunit 2 (20 kDa nuclear cap-binding protein) (Cell proliferation-inducing gene 55 protein) (NCBP 20 kDa subunit) (CBP20) (NCBP-interacting protein 1) (NIP1)
Gene: NCBP2

Interactor 2: DYRK2 (Q92630)
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1)
Gene: DYRK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 156 Hs			1 601
+	Hs
		516362 PABP1_HUMAN (4-156): 7.45e-28: 109: 18.41		CDK2_HUMAN (219-543): 6.32e-142: 415: 27.71
+	Hs
		853885 NCBP2_HUMAN (1-156): 2.27e-48: 154: 100.00		DYR1A_HUMAN (211-537): 2.66e-117: 367: 42.52
+	Hs
		625400 ELAV2_HUMAN (33-122): 1.29e-25: 101: 21.11		CDK2_HUMAN (219-543): 6.32e-142: 415: 27.71
+	Hs
		625633 PUF60_HUMAN (30-113): 1.88e-17: 80.1: 30.95		CDK2_HUMAN (219-543): 6.32e-142: 415: 27.71
+	Hs
		625359 RBM3_HUMAN (42-116): 2.8e-18: 78.1: 36.00		CDK2_HUMAN (219-543): 6.32e-142: 415: 27.71
+	Hs
		969086 ELAV1_HUMAN (7-123): 1.27e-24: 98.4: 18.49		KPCE_HUMAN (55-510): 3.31e-123: 382: 16.70
+	Hs
		516508 PABP1_HUMAN (4-156): 7.45e-28: 109: 18.41		DYR1A_HUMAN (211-537): 2.66e-117: 367: 42.52
+	Mm
		554885 TIA1_MOUSE (1-140): 7e-21: 89.1: 19.58		KPCE_MOUSE (55-510): 2.32e-124: 385: 16.70
+	Hs
		1031320 PABP4_HUMAN (4-156): 2.89e-27: 107: 17.18		DYR1A_HUMAN (211-537): 2.66e-117: 367: 42.52
+	Hs
		414931 ELAV1_HUMAN (7-123): 1.27e-24: 98.4: 18.49		CDK1_HUMAN (219-538): 9.81e-126: 373: 27.13
+	Mm
		554897 TIAR_MOUSE (1-155): 2.19e-19: 84.9: 16.46		KPCE_MOUSE (55-510): 2.32e-124: 385: 16.70
+	Hs
		1020254 ELAV2_HUMAN (33-122): 1.29e-25: 101: 21.11		DYR1A_HUMAN (211-537): 2.66e-117: 367: 42.52
+	Hs
		642764 ELAV4_HUMAN (38-123): 3.21e-25: 100: 24.42		DYR1A_HUMAN (211-537): 2.66e-117: 367: 42.52
+	Hs
		1043817 ELAV1_HUMAN (7-123): 1.27e-24: 98.4: 18.49		DYR1A_HUMAN (211-537): 2.66e-117: 367: 42.52
+	Hs
		1043793 ELAV3_HUMAN (5-122): 3.32e-24: 98: 16.67		DYR1A_HUMAN (211-537): 2.66e-117: 367: 42.52
+	Hs
		1043781 CIRBP_HUMAN (42-126): 4.4e-21: 85.9: 36.47		DYR1A_HUMAN (211-537): 2.66e-117: 367: 42.52
+	Hs
		516416 PABP1_HUMAN (4-156): 7.45e-28: 109: 18.41		CLK2_HUMAN (204-543): 6.41e-57: 201: 31.56
+	Hs
		833874 ELAV2_HUMAN (33-122): 1.29e-25: 101: 21.11		CLK2_HUMAN (204-543): 6.41e-57: 201: 31.56