HitPredict

Interactor 1: VAV2 (P52735)
Guanine nucleotide exchange factor VAV2 (VAV-2)
Gene: VAV2

Interactor 2: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~Ras, PH~Ras, Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016477 - cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 878 Hs			1 193
+	Hs
		855782 VAV2_HUMAN (1-878): 0: 658: 100.00		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		855778 VAV2_HUMAN (1-878): 0: 658: 100.00		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		901037 VAV3_HUMAN (1-875): 1.54e-178: 538: 49.61		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		925718 VAV3_HUMAN (1-875): 1.54e-178: 538: 49.61		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		951449 VAV3_HUMAN (1-875): 1.54e-178: 538: 49.61		RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40
+	Hs
		548672 VAV_HUMAN (1-875): 8.4e-175: 529: 47.20		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		548678 VAV_HUMAN (1-875): 8.4e-175: 529: 47.20		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		548671 VAV_HUMAN (1-875): 8.4e-175: 529: 47.20		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Ce
		975575 VAV_CAEEL (2-874): 6.14e-125: 403: 24.65		RAC1_CAEEL (1-193): 2.07e-80: 238: 55.44
+	Ce
		104467 VAV_CAEEL (2-874): 6.14e-125: 403: 24.65		G5EBV3_CAEEL (2-193): 1.08e-77: 232: 50.52
+	Ce
		1094614 VAV_CAEEL (2-874): 6.14e-125: 403: 24.65		RHO1_CAEEL (1-192): 2.25e-75: 226: 85.94
+	Dm
		776903 VAV_DROME (2-582): 1.29e-114: 370: 31.54		RAC1_DROME (1-193): 2.11e-77: 231: 54.12
+	Hs
		500932 MCF2_HUMAN (8-613): 6.72e-83: 287: 16.14		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		500934 MCF2_HUMAN (8-613): 6.72e-83: 287: 16.14		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		50546 PKHG3_HUMAN (201-564): 2.15e-81: 287: 24.67		RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71
+	Hs
		500931 MCF2_HUMAN (8-613): 6.72e-83: 287: 16.14		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		50572 PKHG3_HUMAN (201-564): 2.15e-81: 287: 24.67		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		50554 PKHG3_HUMAN (201-564): 2.15e-81: 287: 24.67		RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61
+	Hs
		50571 PKHG3_HUMAN (201-564): 2.15e-81: 287: 24.67		RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54
+	Hs
		50535 PKHG3_HUMAN (201-564): 2.15e-81: 287: 24.67		RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98