HitPredict

Interactor 1: PHAG1 (Q3U1F9)
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane phosphoprotein Cbp)
Gene: Pag1

Interactor 2: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.646

Property	Details
Experiments	26512138
Identification Methods	affinity chromatography technology
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	PAG~SH2
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 429 Mm			1 217
+	Hs
		987977 PHAG1_HUMAN (1-429): 0: 705: 78.21		GRB2_HUMAN (1-217): 4.48e-72: 219: 99.54
+	Mm
		834252 PHAG1_MOUSE (1-429): 0: 785: 100.00		CSK_MOUSE (2-139): 1.13e-23: 99.4: 35.57
+	Mm
		1189758 PHAG1_MOUSE (1-429): 0: 785: 100.00		NCK1_MOUSE (5-145): 9.03e-23: 96.3: 33.14
+	Rn
		740515 PHAG1_RAT (1-429): 0: 764: 89.51		CSK_RAT (2-139): 1.15e-23: 99.4: 35.57
+	Mm
		699353 PHAG1_MOUSE (1-429): 0: 785: 100.00		VAV_MOUSE (3-60): 1.02e-15: 77.3: 43.10
+	Mm
		813516 PHAG1_MOUSE (1-429): 0: 785: 100.00		FYN_MOUSE (161-215): 1.26e-13: 70.8: 31.58
+	Mm
		683095 PHAG1_MOUSE (1-429): 0: 785: 100.00		LYN_MOUSE (135-215): 3.19e-10: 60.7: 24.10
+	Hs
		440227 PHAG1_HUMAN (1-429): 0: 705: 78.21		LCK_HUMAN (3-202): 4.02e-36: 134: 27.49
+	Hs
		841030 PHAG1_HUMAN (1-429): 0: 705: 78.21		FRK_HUMAN (3-202): 6.21e-35: 131: 28.37
+	Hs
		834233 PHAG1_HUMAN (1-429): 0: 705: 78.21		CSK_HUMAN (2-139): 4.26e-24: 100: 36.24
+	Hs
		362387 PHAG1_HUMAN (1-429): 0: 705: 78.21		ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46
+	Hs
		584589 PHAG1_HUMAN (1-429): 0: 705: 78.21		VAV_HUMAN (3-60): 1.48e-15: 76.5: 43.10
+	Hs
		440751 PHAG1_HUMAN (1-429): 0: 705: 78.21		FYN_HUMAN (161-215): 1.22e-13: 71.1: 31.58
+	Hs
		557496 PHAG1_HUMAN (1-429): 0: 705: 78.21		SRC_HUMAN (160-215): 2.32e-11: 64.2: 31.03
+	Hs
		463801 PHAG1_HUMAN (1-429): 0: 705: 78.21		LYN_HUMAN (135-215): 9.03e-11: 62.7: 24.10