HitPredict

Interactor 1: RING1 (Q06587)
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein)
Gene: RING1

Interactor 2: PCGF3 (Q3KNV8)
Polycomb group RING finger protein 3 (RING finger protein 3A)
Gene: PCGF3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.953

Property	Details
Experiments	27705803, 24981860, 32296183, 22325352, 22493164, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, tandem affinity purification, two hybrid array, validated two hybrid, two hybrid prey pooling approach, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	RAWUL~RAWUL, zf-C3HC4_2~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031519 - PcG protein complex GO:0035102 - PRC1 complex GO:0046872 - metal ion binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 406 Hs			1 242
+	Mm
		193404 RING1_MOUSE (1-406): 2.17e-118: 352: 96.55		BMI1_MOUSE (3-238): 5e-59: 191: 33.48
+	Mm
		193403 RING1_MOUSE (1-406): 2.17e-118: 352: 96.55		PCGF2_MOUSE (3-238): 2.56e-56: 184: 34.18
+	Hs
		717742 RING1_HUMAN (1-406): 2.01e-114: 342: 100.00		BMI1_HUMAN (3-238): 2.96e-60: 194: 33.76
+	Hs
		988039 RING1_HUMAN (1-406): 2.01e-114: 342: 100.00		R4GMX3_HUMAN (3-238): 7.96e-59: 194: 33.76
+	Hs
		718393 RING1_HUMAN (1-406): 2.01e-114: 342: 100.00		PCGF2_HUMAN (3-238): 5.76e-59: 191: 34.03
+	Mm
		1207257 RING2_MOUSE (8-406): 2.94e-100: 303: 54.25		PCGF3_MOUSE (1-242): 1.74e-64: 202: 97.52
+	Hs
		988015 RING1_HUMAN (1-406): 2.01e-114: 342: 100.00		PCGF1_HUMAN (3-238): 1.66e-45: 154: 38.33
+	Mm
		639478 RING2_MOUSE (8-406): 2.94e-100: 303: 54.25		BMI1_MOUSE (3-238): 5e-59: 191: 33.48
+	Hs
		988016 RING1_HUMAN (1-406): 2.01e-114: 342: 100.00		PCGF6_HUMAN (3-235): 4.63e-43: 150: 33.62
+	Mm
		620793 RING2_MOUSE (8-406): 2.94e-100: 303: 54.25		PCGF2_MOUSE (3-238): 2.56e-56: 184: 34.18
+	Mm
		193402 RING1_MOUSE (1-406): 2.17e-118: 352: 96.55		RING1_MOUSE (3-182): 7.06e-36: 133: 20.22
+	Mm
		193415 RING1_MOUSE (1-406): 2.17e-118: 352: 96.55		RING2_MOUSE (2-237): 2.47e-36: 132: 18.00
+	Hs
		987986 RING1_HUMAN (1-406): 2.01e-114: 342: 100.00		PCGF5_HUMAN (4-241): 3.95e-40: 140: 38.06
+	Hs
		988012 RING1_HUMAN (1-406): 2.01e-114: 342: 100.00		RING2_HUMAN (2-237): 3.42e-36: 132: 18.00
+	Hs
		987956 RING1_HUMAN (1-406): 2.01e-114: 342: 100.00		RING1_HUMAN (3-172): 3.16e-35: 131: 20.81
+	Mm
		1246747 RING2_MOUSE (8-406): 2.94e-100: 303: 54.25		PCGF1_MOUSE (3-238): 7.57e-45: 152: 39.17
+	Mm
		1307909 RING2_MOUSE (8-406): 2.94e-100: 303: 54.25		PCGF6_MOUSE (3-235): 2.09e-40: 143: 34.04
+	Mm
		1112809 RING2_MOUSE (8-406): 2.94e-100: 303: 54.25		PCGF5_MOUSE (4-241): 3.86e-40: 140: 37.69
+	Mm
		1321732 RING2_MOUSE (8-406): 2.94e-100: 303: 54.25		RING2_MOUSE (2-237): 2.47e-36: 132: 18.00