HitPredict

Interactor 1: PLK1 (P53350)
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
Gene: PLK1

Interactor 2: STXB4 (Q6ZWJ1)
Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (STX4-interacting protein) (Synip)
Gene: STXBP4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.50	0.609

Property	Details
Experiments	28514442, 25659891, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 603 Hs			1 553
+	Hs
		150689 PLK1_HUMAN (1-603): 0: 617: 100.00		DVL1_HUMAN (2-192): 2.77e-31: 130: 14.67
+	Hs
		150919 PLK1_HUMAN (1-603): 0: 617: 100.00		DVL2_HUMAN (2-192): 2.86e-30: 127: 16.90
+	Hs
		861861 PLK1_HUMAN (1-603): 0: 617: 100.00		PARD3_HUMAN (5-241): 1.88e-24: 110: 18.60
+	Ce
		711697 PLK1_CAEEL (22-599): 0: 536: 50.58		Q9BIC1_CAEEL (18-93): 1.11e-17: 89: 32.05
+	Rn
		291511 PLK2_RAT (6-587): 1.9e-166: 492: 35.43		MAGI2_RAT (21-157): 4.55e-15: 80.6: 21.83
+	Hs
		1033837 KS6A1_HUMAN (1-362): 5.61e-109: 345: 24.87		SNTA1_HUMAN (4-234): 6.27e-35: 139: 17.80
+	Hs
		150707 KS6A2_HUMAN (1-367): 4.14e-105: 335: 22.43		DVL1_HUMAN (2-192): 2.77e-31: 130: 14.67
+	Hs
		1071685 KS6A2_HUMAN (1-367): 4.14e-105: 335: 22.43		NEB2_HUMAN (7-242): 4.94e-30: 127: 18.03
+	Hs
		1073454 KS6A1_HUMAN (1-362): 5.61e-109: 345: 24.87		PAR3L_HUMAN (3-133): 2.15e-17: 88.3: 24.82
+	Hs
		150772 AURKA_HUMAN (28-307): 4.39e-43: 160: 32.17		DVL2_HUMAN (2-192): 2.86e-30: 127: 16.90
+	Ce
		136338 AIR2_CAEEL (35-314): 4.72e-41: 152: 32.06		Q9BIC1_CAEEL (18-93): 1.11e-17: 89: 32.05
+	Ce
		136331 AIR2_CAEEL (35-314): 4.72e-41: 152: 32.06		P90976_CAEEL (13-101): 2.23e-18: 87.9: 30.34