HitPredict

Interactor 1: NEDD4 (P46935)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Interactor 2: SCN8A (Q9WTU3)
Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6)
Gene: SCN8A

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	15123669
Identification Methods	far western blotting
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006814 - sodium ion transport GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 887 Mm			1 1978
+	Mm
		73088 NEDD4_MOUSE (1-887): 0: 946: 100.00		SCN2A_MOUSE (1-1977): 0: 1963: 72.80
+	Mm
		861880 NEDD4_MOUSE (1-887): 0: 946: 100.00		SCN9A_MOUSE (4-1972): 0: 1910: 68.43
+	Hs
		861842 NEDD4_HUMAN (157-887): 0: 735: 79.83		SCN8A_HUMAN (1-1978): 0: 2037: 98.23
+	Mm
		861885 NEDD4_MOUSE (1-887): 0: 946: 100.00		SCNAA_MOUSE (6-1975): 0: 1780: 53.11
+	Hs
		771743 NEDD4_HUMAN (157-887): 0: 735: 79.83		SCN1A_HUMAN (1-1966): 0: 1902: 72.54
+	Mm
		73078 E9PXB7_MOUSE (172-887): 0: 673: 56.84		SCN2A_MOUSE (1-1977): 0: 1963: 72.80
+	Hs
		1155140 SMUF2_HUMAN (79-883): 0: 677: 34.20		SCN9A_HUMAN (4-1977): 0: 1919: 69.41
+	Mm
		97741 E9PXB7_MOUSE (172-887): 0: 673: 56.84		SCN9A_MOUSE (4-1972): 0: 1910: 68.43
+	Hs
		1127634 NED4L_HUMAN (70-887): 0: 778: 56.22		SCN5A_HUMAN (3-1939): 0: 1804: 61.44
+	Hs
		771756 SMUF2_HUMAN (79-883): 0: 677: 34.20		SCN1A_HUMAN (1-1966): 0: 1902: 72.54
+	Hs
		861611 NEDD4_HUMAN (157-887): 0: 735: 79.83		SCN5A_HUMAN (3-1939): 0: 1804: 61.44
+	Hs
		132037 WWP2_HUMAN (75-884): 0: 681: 33.33		SCN5A_HUMAN (3-1939): 0: 1804: 61.44
+	Hs
		1127640 SMUF2_HUMAN (79-883): 0: 677: 34.20		SCN5A_HUMAN (3-1939): 0: 1804: 61.44
+	Hs
		861860 NEDD4_HUMAN (157-887): 0: 735: 79.83		SCNAA_HUMAN (6-1973): 0: 1734: 53.71
+	Mm
		97743 E9PXB7_MOUSE (172-887): 0: 673: 56.84		SCNAA_MOUSE (6-1975): 0: 1780: 53.11
+	Mm
		861869 NEDD4_MOUSE (1-887): 0: 946: 100.00		Q3UF73_MOUSE (1-205): 2.03e-95: 308: 72.68
+	Mm
		861901 NEDD4_MOUSE (1-887): 0: 946: 100.00		SCN5A_MOUSE (343-653): 1.05e-13: 79.5: 12.01
+	Mm
		97737 E9PXB7_MOUSE (172-887): 0: 673: 56.84		Q3UF73_MOUSE (1-205): 2.03e-95: 308: 72.68
+	Hs
		1119261 NED4L_HUMAN (70-887): 0: 778: 56.22		CAC1C_HUMAN (20-336): 2e-15: 84.9: 16.32
+	Hs
		132025 WWP2_HUMAN (75-884): 0: 681: 33.33		CAC1C_HUMAN (20-336): 2e-15: 84.9: 16.32