HitPredict

Interactor 1: E9PXB7 (E9PXB7)
E3 ubiquitin-protein ligase (EC 2.3.2.26)
Gene: Nedd4l

Interactor 2: Q3UF73 (Q3UF73)
Ion transport domain-containing protein
Gene: Scn3a

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.50	0.457

Property	Details
Experiments	15123669
Identification Methods	far western blotting
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 835 Mm			1 201
+	Mm
		97743 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCNAA_MOUSE (110-201): 4.74e-10: 60: 17.35
+	Mm
		97752 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCN5A_MOUSE (101-201): 7.2e-10: 59.7: 20.37
+	Mm
		97754 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCN8A_MOUSE (78-201): 6.79e-10: 59.7: 21.54
+	Mm
		73078 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCN2A_MOUSE (78-201): 2.27e-09: 58.1: 19.23
+	Mm
		97741 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCN9A_MOUSE (78-201): 3.78e-09: 57.7: 19.23
+	Hs
		1119261 NED4L_HUMAN (1-835): 0: 944: 95.79		CAC1C_HUMAN (123-199): 2.09e-11: 64.3: 21.69
+	Hs
		1127634 NED4L_HUMAN (1-835): 0: 944: 95.79		SCN5A_HUMAN (110-201): 1.88e-09: 58.5: 20.41
+	Hs
		861860 NEDD4_HUMAN (1-835): 0: 846: 60.41		SCNAA_HUMAN (78-201): 3.38e-12: 66.6: 21.54
+	Hs
		861842 NEDD4_HUMAN (1-835): 0: 846: 60.41		SCN8A_HUMAN (78-201): 7.19e-10: 59.7: 21.54
+	Hs
		771743 NEDD4_HUMAN (1-835): 0: 846: 60.41		SCN1A_HUMAN (78-201): 1.12e-09: 59.3: 19.23
+	Hs
		861611 NEDD4_HUMAN (1-835): 0: 846: 60.41		SCN5A_HUMAN (110-201): 1.88e-09: 58.5: 20.41
+	Mm
		861869 NEDD4_MOUSE (10-135): 1.9e-17: 89.5: 16.67		Q3UF73_MOUSE (1-201): 4.76e-100: 289: 100.00
+	Hs
		132025 WWP2_HUMAN (24-172): 1.67e-20: 99.1: 20.00		CAC1C_HUMAN (123-199): 2.09e-11: 64.3: 21.69
+	Hs
		771756 SMUF2_HUMAN (11-105): 1.72e-21: 102: 26.85		SCN1A_HUMAN (78-201): 1.12e-09: 59.3: 19.23
+	Hs
		1127640 SMUF2_HUMAN (11-105): 1.72e-21: 102: 26.85		SCN5A_HUMAN (110-201): 1.88e-09: 58.5: 20.41
+	Hs
		1155140 SMUF2_HUMAN (11-105): 1.72e-21: 102: 26.85		SCN9A_HUMAN (78-201): 1.99e-09: 58.5: 20.00
+	Hs
		132037 WWP2_HUMAN (24-172): 1.67e-20: 99.1: 20.00		SCN5A_HUMAN (110-201): 1.88e-09: 58.5: 20.41
+	Hs
		139717 HECW1_HUMAN (153-500): 2.69e-18: 92.6: 16.54		CAC1A_HUMAN (125-201): 6.15e-11: 62.7: 21.69
+	Mm
		73088 NEDD4_MOUSE (10-135): 1.9e-17: 89.5: 16.67		SCN2A_MOUSE (78-201): 2.27e-09: 58.1: 19.23
+	Mm
		861880 NEDD4_MOUSE (10-135): 1.9e-17: 89.5: 16.67		SCN9A_MOUSE (78-201): 3.78e-09: 57.7: 19.23