HitPredict

Interactor 1: E9PXB7 (E9PXB7)
E3 ubiquitin-protein ligase (EC 2.3.2.26)
Gene: Nedd4l

Interactor 2: SCNAA (Q6QIY3)
Sodium channel protein type 10 subunit alpha (Peripheral nerve sodium channel 3) (PN3) (Sensory neuron sodium channel) (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8)
Gene: Scn10a

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.50	0.457

Property	Details
Experiments	15123669
Identification Methods	far western blotting
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 835 Mm			1 1958
+	Hs
		861860 NEDD4_HUMAN (1-835): 0: 846: 60.41		SCNAA_HUMAN (1-1957): 0: 1885: 82.23
+	Mm
		97741 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCN9A_MOUSE (5-1950): 0: 1753: 52.88
+	Mm
		97752 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCN5A_MOUSE (5-1948): 0: 1752: 60.73
+	Hs
		1127634 NED4L_HUMAN (1-835): 0: 944: 95.79		SCN5A_HUMAN (5-1948): 0: 1740: 59.86
+	Mm
		97754 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCN8A_MOUSE (5-1953): 0: 1691: 52.45
+	Hs
		861611 NEDD4_HUMAN (1-835): 0: 846: 60.41		SCN5A_HUMAN (5-1948): 0: 1740: 59.86
+	Hs
		771743 NEDD4_HUMAN (1-835): 0: 846: 60.41		SCN1A_HUMAN (5-1943): 0: 1732: 52.49
+	Hs
		861842 NEDD4_HUMAN (1-835): 0: 846: 60.41		SCN8A_HUMAN (5-1953): 0: 1686: 52.21
+	Mm
		861885 NEDD4_MOUSE (10-135): 1.9e-17: 89.5: 16.67		SCNAA_MOUSE (1-1958): 0: 1978: 100.00
+	Mm
		861880 NEDD4_MOUSE (10-135): 1.9e-17: 89.5: 16.67		SCN9A_MOUSE (5-1950): 0: 1753: 52.88
+	Hs
		1127640 SMUF2_HUMAN (11-105): 1.72e-21: 102: 26.85		SCN5A_HUMAN (5-1948): 0: 1740: 59.86
+	Mm
		861901 NEDD4_MOUSE (10-135): 1.9e-17: 89.5: 16.67		SCN5A_MOUSE (5-1948): 0: 1752: 60.73
+	Hs
		132037 WWP2_HUMAN (24-172): 1.67e-20: 99.1: 20.00		SCN5A_HUMAN (5-1948): 0: 1740: 59.86
+	Hs
		771756 SMUF2_HUMAN (11-105): 1.72e-21: 102: 26.85		SCN1A_HUMAN (5-1943): 0: 1732: 52.49
+	Mm
		73078 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCN2A_MOUSE (625-1121): 3.17e-45: 183: 16.82
+	Hs
		1119261 NED4L_HUMAN (1-835): 0: 944: 95.79		CAC1C_HUMAN (21-525): 9.45e-20: 99.1: 13.65
+	Hs
		1155140 SMUF2_HUMAN (11-105): 1.72e-21: 102: 26.85		SCN9A_HUMAN (625-1122): 1.15e-45: 184: 16.10
+	Mm
		73088 NEDD4_MOUSE (10-135): 1.9e-17: 89.5: 16.67		SCN2A_MOUSE (625-1121): 3.17e-45: 183: 16.82
+	Hs
		139717 HECW1_HUMAN (153-500): 2.69e-18: 92.6: 16.54		CAC1A_HUMAN (43-645): 1.98e-33: 144: 15.44
+	Hs
		132025 WWP2_HUMAN (24-172): 1.67e-20: 99.1: 20.00		CAC1C_HUMAN (21-525): 9.45e-20: 99.1: 13.65