HitPredict

Interactor 1: PLK1 (P53350)
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
Gene: PLK1

Interactor 2: RGAP1 (Q9H0H5)
Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4)
Gene: RACGAP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.78 1.00 0.884

The method score is based on:

Property Details
Experiments 25486482, 19468300, 19468302
Identification Methods enzymatic study, protein kinase assay, far western blotting, anti bait coimmunoprecipitation
Interaction Type direct interaction, phosphorylation reaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains C1_1~Pkinase
Common GO terms GO:0000281 - mitotic cytokinesis
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005819 - spindle
GO:0005829 - cytosol
and 4 others

more...
Homologous interactions 6

Homologous interactions

Color coding for hit scores

1 603
Hs

1 632
+ Hs
+ Dm
+ Hs
+ Hs
+ Ce
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024