Protein: CSTF2
Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64)

Gene: CSTF2
Organism: Homo sapiens
Interactions: 141
UniProt ID: P33240

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0003729 - mRNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

750476

CSTFT
Cleavage stimulation factor subunit 2 tau variant

4

15

High-throughput

0.895

High

750413

CSTF3
Cleavage stimulation factor subunit 3

3

12

Small-scale

0.853

High

340729

CPSF4
Cleavage and polyadenylation specificity factor subunit 4

2

11

High-throughput

0.789

High

750478

STPAP
Speckle targeted PIP5K1A-regulated poly(A) polymerase

2

3

Small-scale

0.754

High

750463

SYMPK
Symplekin

5

3

Small-scale

0.721

High

750497

UBQL1
Ubiquilin-1

4

11

High-throughput

0.705

High

750412

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

8

High-throughput

0.698

High

477932

SNRPA
U1 small nuclear ribonucleoprotein A

1

19

High-throughput

0.691

High

750393

FUS
RNA-binding protein FUS

1

18

High-throughput

0.691

High

750424

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

15

High-throughput

0.691

High

750466

RBM14
RNA-binding protein 14

1

17

High-throughput

0.691

High

750479

MKNK2
MAP kinase-interacting serine/threonine-protein kinase 2

1

1

High-throughput

0.691

High

750468

BARD1
BRCA1-associated RING domain protein 1

3

5

Small-scale

0.683

High

750469

SPAG8
Sperm-associated antigen 8

3

1

High-throughput

0.675

High

750494

CPSF3
Cleavage and polyadenylation specificity factor subunit 3

3

10

Small-scale

0.675

High

750492

UBQL2
Ubiquilin-2

3

11

High-throughput

0.653

High

750394

BRCA1
Breast cancer type 1 susceptibility protein

2

10

Small-scale

0.635

High

750473

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

2

20

High-throughput

0.618

High

472477

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

17

High-throughput

0.618

High

750405

EWS
RNA-binding protein EWS

1

12

High-throughput

0.618

High

750411

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

5

Small-scale

0.618

High

750416

TIF1B
Transcription intermediary factor 1-beta

1

8

Small-scale

0.618

High

750423

ELAV1
ELAV-like protein 1

1

15

High-throughput

0.618

High

750491

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.618

High

169457

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

3

1

High-throughput

0.616

High

750462

TFG
Protein TFG

3

3

High-throughput

0.616

High

750490

CPSF2
Cleavage and polyadenylation specificity factor subunit 2

2

9

Small-scale

0.611

High

750400

CTBP2
C-terminal-binding protein 2

2

4

High-throughput

0.606

High

750406

TLE3
Transducin-like enhancer protein 3

2

5

High-throughput

0.606

High

750408

TLE5
TLE family member 5

2

2

High-throughput

0.606

High

750441

RFX6
DNA-binding protein RFX6

2

1

High-throughput

0.606

High

750442

STH
Saitohin

2

1

High-throughput

0.606

High

750484

ANR10
Ankyrin repeat domain-containing protein 10

2

3

High-throughput

0.606

High

750488

CNOT2
CCR4-NOT transcription complex subunit 2

2

3

High-throughput

0.606

High

750496

AKP8L
A-kinase anchor protein 8-like

2

1

High-throughput

0.606

High

750399

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

1

Small-scale

0.586

High

259519

BRD4
Bromodomain-containing protein 4

2

6

High-throughput

0.584

High

750403

PO6F2
POU domain, class 6, transcription factor 2

2

0

High-throughput

0.580

High

750410

INCA1
Protein INCA1

2

0

High-throughput

0.580

High

750470

HDHD3
Haloacid dehalogenase-like hydrolase domain-containing protein 3

2

0

High-throughput

0.580

High

750481

PRDM6
Putative histone-lysine N-methyltransferase PRDM6

2

0

High-throughput

0.580

High

273980

CREST
Calcium-responsive transactivator

1

1

High-throughput

0.573

High

750472

ZN341
Zinc finger protein 341

1

1

High-throughput

0.573

High

750436

RHG22
Rho GTPase-activating protein 22

2

3

High-throughput

0.571

High

667187

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

4

Small-scale

0.561

High

50322

F168B
Myelin-associated neurite-outgrowth inhibitor

2

1

High-throughput

0.553

High

750395

CEAM6
Cell adhesion molecule CEACAM6

2

4

High-throughput

0.553

High

750454

ABHDB
sn-1-specific diacylglycerol lipase ABHD11

2

1

High-throughput

0.553

High

750498

ATP23
Mitochondrial inner membrane protease ATP23 homolog

2

1

High-throughput

0.553

High

687902

EF1G
Elongation factor 1-gamma

1

2

High-throughput

0.541

High

750397

BAG6
Large proline-rich protein BAG6

1

11

High-throughput

0.541

High

750425

MIC60
MICOS complex subunit MIC60

1

1

High-throughput

0.541

High

750464

KAT5
Histone acetyltransferase KAT5

1

2

High-throughput

0.541

High

750482

UBQL4
Ubiquilin-4

1

15

High-throughput

0.541

High

337317

PARN
Poly(A)-specific ribonuclease PARN

1

1

Small-scale

0.536

High

480042

RU1C
U1 small nuclear ribonucleoprotein C

1

1

High-throughput

0.536

High

541851

TOP1
DNA topoisomerase 1

1

1

High-throughput

0.536

High

574152

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

3

High-throughput

0.536

High

750409

SSRP1
FACT complex subunit SSRP1

1

5

High-throughput

0.536

High

750431

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

5

High-throughput

0.536

High

750480

SSU72
RNA polymerase II subunit A C-terminal domain phosphatase SSU72

1

0

High-throughput

0.530

High

165452

RGRF2
Ras-specific guanine nucleotide-releasing factor 2

2

5

High-throughput

0.521

High

327558

ELP1
Elongator complex protein 1

1

0

High-throughput

0.518

High

750418

SMC1A
Structural maintenance of chromosomes protein 1A

1

1

High-throughput

0.515

High

750430

CDC73
Parafibromin

1

0

Small-scale

0.513

High

421588

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

269439

KI21B
Kinesin-like protein KIF21B

1

1

High-throughput

0.489

High

750459

TSC1
Hamartin

1

7

High-throughput

0.481

High

240884

PRKN
E3 ubiquitin-protein ligase parkin

1

15

High-throughput

0.479

High

247697

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

324582

HEXI1
Protein HEXIM1

1

6

High-throughput

0.479

High

588024

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

694738

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

750392

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.479

High

750396

CCNF
Cyclin-F

1

6

High-throughput

0.479

High

750398

MECP2
Methyl-CpG-binding protein 2

1

7

High-throughput

0.479

High

750401

H4
Histone H4

1

7

High-throughput

0.479

High

750404

RUNX1
Runt-related transcription factor 1

1

3

High-throughput

0.479

High

750407

CSTF1
Cleavage stimulation factor subunit 1

1

7

Small-scale

0.479

High

750415

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

2

High-throughput

0.479

High

750417

CUL4B
Cullin-4B

1

20

High-throughput

0.479

High

750420

KIF14
Kinesin-like protein KIF14

1

9

High-throughput

0.479

High

750421

RAGE
Advanced glycosylation end product-specific receptor

1

5

High-throughput

0.479

High

750435

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.479

High

750438

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

10

Small-scale

0.479

High

750443

SMC5
Structural maintenance of chromosomes protein 5

1

6

High-throughput

0.479

High

750444

SLX4
Structure-specific endonuclease subunit SLX4

1

3

High-throughput

0.479

High

750445

SRRM1
Serine/arginine repetitive matrix protein 1

1

7

High-throughput

0.479

High

750455

TNIP2
TNFAIP3-interacting protein 2

1

3

High-throughput

0.479

High

750457

DDX1
ATP-dependent RNA helicase DDX1

1

8

Small-scale

0.479

High

750458

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

750460

AKAP1
A-kinase anchor protein 1, mitochondrial

1

7

High-throughput

0.479

High

750461

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

750471

FACD2
Fanconi anemia group D2 protein

1

4

High-throughput

0.479

High

750474

WDR33
pre-mRNA 3' end processing protein WDR33

1

5

High-throughput

0.479

High

750475

WWTR1
WW domain-containing transcription regulator protein 1

1

13

High-throughput

0.479

High

750483

KTU
Protein kintoun

1

2

High-throughput

0.479

High

750485

AATF
Protein AATF

1

1

High-throughput

0.479

High

750486

WWOX
WW domain-containing oxidoreductase

1

4

High-throughput

0.479

High

750493

ANC2
Anaphase-promoting complex subunit 2

1

20

High-throughput

0.479

High

750446

KT222
Keratin-like protein KRT222

1

1

High-throughput

0.470

High

46360

A0A1U9X8X8
Corneodesmosin

1

3

High-throughput

0.470

High

750440

Q86WV8
TSC complex subunit 1

1

1

High-throughput

0.470

High

291624

XRP2
Protein XRP2

1

0

High-throughput

0.458

High

750439

UBE3D
E3 ubiquitin-protein ligase E3D

1

0

High-throughput

0.458

High

750453

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

750487

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.458

High

750422

CDSN
Corneodesmosin

1

3

High-throughput

0.439

High

105442

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

271935

OBSL1
Obscurin-like protein 1

1

6

High-throughput

0.437

High

293279

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.437

High

318637

RHBT1
Rho-related BTB domain-containing protein 1

1

5

High-throughput

0.437

High

375229

RASK
GTPase KRas

1

3

High-throughput

0.437

High

415994

CP1A1
Cytochrome P450 1A1

1

1

High-throughput

0.437

High

750402

ACTC
Actin, alpha cardiac muscle 1

1

4

High-throughput

0.437

High

750419

CUL7
Cullin-7

1

5

High-throughput

0.437

High

750427

RN123
E3 ubiquitin-protein ligase RNF123

1

2

High-throughput

0.437

High

750428

A16L1
Autophagy-related protein 16-1

1

11

High-throughput

0.437

High

750433

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.437

High

750447

FBXL6
F-box/LRR-repeat protein 6

1

1

High-throughput

0.437

High

750448

S2541
Mitochondrial carrier protein SCaMC-3L

1

1

High-throughput

0.437

High

750449

NGEF
Ephexin-1

1

7

High-throughput

0.437

High

750452

TTC29
Tetratricopeptide repeat protein 29

1

3

High-throughput

0.437

High

750456

TIP
T-cell immunomodulatory protein

1

2

High-throughput

0.437

High

750477

PKHA4
Pleckstrin homology domain-containing family A member 4

1

13

High-throughput

0.437

High

404702

PRIO
Major prion protein

1

1

High-throughput

0.407

High

750465

C170L
Cep170-like protein

1

2

High-throughput

0.407

High

66141

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

2

0

High-throughput

0.316

High

750429

UFSP1
Ufm1-specific protease 1

2

0

High-throughput

0.316

High

750434

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

2

0

High-throughput

0.316

High

750437

SAXO4
Stabilizer of axonemal microtubules 4

2

0

High-throughput

0.316

High

750450

MET27
Methyltransferase-like protein 27

2

0

High-throughput

0.316

High

166257

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

2

0

High-throughput

0.298

High

750414

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

0

High-throughput

0.282

High

750467

FEZ1
Fasciculation and elongation protein zeta-1

1

0

High-throughput

0.282

High

750489

CE126
Centrosomal protein of 126 kDa

1

0

High-throughput

0.282

High

750495

ERG28
Ergosterol biosynthetic protein 28 homolog

1

0

High-throughput

0.282

High

566924

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.279

Low

750432

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

750426

LETM2
LETM1 domain-containing protein LETM2, mitochondrial

1

0

High-throughput

0.232

Low

750451

S35G3
Solute carrier family 35 member G3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025