Interactor 1: ITSN1 (Q15811)
Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17)
Gene: ITSN1
Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH
Species: Homo sapiens
Source: biogrid
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.52 | 1.00 | 0.724 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 26613292 |
| Identification Methods | fluorescent resonance energy transfer, affinity chromatography technology |
| Interaction Type | direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | C2~C2, C2~SH3_1 |
| Common GO terms | GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane |
| Homologous interactions | 9 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
