HitPredict

Interactor 1: PLK1 (P53350)
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
Gene: PLK1

Interactor 2: FBX5 (Q9UKT4)
F-box only protein 5 (Early mitotic inhibitor 1)
Gene: FBXO5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

The method score is based on:

Property	Details
Experiments	15469984, 16439210
Identification Methods	affinity chromatography technology, protein kinase assay
Interaction Type	physical association, phosphorylation reaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005819 - spindle GO:0005829 - cytosol and 4 others more... GO:0007346 - regulation of mitotic cell cycle GO:0010997 - anaphase-promoting complex binding GO:0016567 - protein ubiquitination GO:0019901 - protein kinase binding
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	603
Hs

1	447

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024