HitPredict

Interactor 1: CXA8 (P48165)
Gap junction alpha-8 protein (Connexin-50) (Cx50) (Lens fiber protein MP70)
Gene: GJA8

Interactor 2: ZO1 (Q07157)
Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1)
Gene: TJP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	12808044
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 433 Hs			1 1748
+	Hs
		1058967 CXA3_HUMAN (1-433): 0: 539: 44.37		ZO1_HUMAN (1-1748): 0: 924: 100.00
+	Hs
		603946 CXA1_HUMAN (1-343): 1.75e-122: 362: 39.48		ZO1_HUMAN (1-1748): 0: 924: 100.00
+	Mm
		655034 CXA1_MOUSE (1-343): 4.8e-123: 364: 39.77		ZO1_MOUSE (1-1748): 0: 871: 90.85
+	Rn
		98865 CXA1_RAT (1-343): 4.8e-123: 364: 39.77		F1M4A0_RAT (27-1748): 0: 863: 90.83
+	Mm
		811941 CXB6_MOUSE (3-238): 8.97e-117: 343: 49.37		ZO1_MOUSE (1-1748): 0: 871: 90.85
+	Hs
		1058881 CXD3_HUMAN (1-238): 4.18e-95: 289: 40.34		ZO1_HUMAN (1-1748): 0: 924: 100.00
+	Hs
		168632 CXA1_HUMAN (1-343): 1.75e-122: 362: 39.48		CSKP_HUMAN (217-806): 9.94e-86: 304: 14.81
+	Hs
		604023 CXA1_HUMAN (1-343): 1.75e-122: 362: 39.48		MPP7_HUMAN (310-807): 5.71e-85: 292: 14.96
+	Hs
		603954 CXA1_HUMAN (1-343): 1.75e-122: 362: 39.48		PTN13_HUMAN (20-492): 4.04e-23: 110: 16.63
+	Rn
		465206 CXA1_RAT (1-343): 4.8e-123: 364: 39.77		Q3ZB99_RAT (1086-1374): 2.75e-20: 100: 20.00
+	Hs
		706037 CXB2_HUMAN (3-240): 5.74e-123: 357: 51.46		INADL_HUMAN (60-583): 5.68e-19: 96.5: 18.77
+	Hs
		604118 CXA1_HUMAN (1-343): 1.75e-122: 362: 39.48		DLG5_HUMAN (262-508): 3.84e-17: 90.3: 21.43
+	Hs
		603956 CXA1_HUMAN (1-343): 1.75e-122: 362: 39.48		DLG1_HUMAN (259-512): 4.27e-17: 90: 16.67
+	Mm
		236493 CXD2_MOUSE (1-265): 2.08e-116: 344: 38.10		ZO2_MOUSE (1086-1374): 4.86e-19: 96.5: 19.66
+	Hs
		328775 CXA1_HUMAN (1-343): 1.75e-122: 362: 39.48		UNC5C_HUMAN (1635-1728): 1.99e-13: 77.8: 47.37
+	Hs
		604088 CXA1_HUMAN (1-343): 1.75e-122: 362: 39.48		UNC5B_HUMAN (1634-1718): 3.5e-11: 70.5: 44.71
+	Hs
		604257 CXA1_HUMAN (1-343): 1.75e-122: 362: 39.48		ZO2_HUMAN (391-609): 2.16e-09: 64.9: 18.62
+	Hs
		464694 CXB1_HUMAN (3-290): 3.69e-111: 330: 40.61		DLG1_HUMAN (259-512): 4.27e-17: 90: 16.67
+	Hs
		1091519 CXB7_HUMAN (4-243): 1.42e-106: 315: 43.80		DLG1_HUMAN (259-512): 4.27e-17: 90: 16.67
+	Hs
		328793 CXD3_HUMAN (1-238): 4.18e-95: 289: 40.34		UNC5C_HUMAN (1635-1728): 1.99e-13: 77.8: 47.37