HitPredict

Interactor 1: TCPE (P48643)
T-complex protein 1 subunit epsilon (TCP-1-epsilon) (EC 3.6.1.-) (CCT-epsilon) (Chaperonin containing T-complex polypeptide 1 subunit 5)
Gene: CCT5

Interactor 2: KTNB1 (Q9BVA0)
Katanin p80 WD40 repeat-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin)
Gene: KATNB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	33961781, 37689310
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cpn60_TCP1~WD40
Common GO terms	GO:0005813 - centrosome GO:0005829 - cytosol GO:0005874 - microtubule
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 541 Hs			1 655
+	Hs
		1407542 TCPH_HUMAN (12-539): 0: 572: 29.64		KTNB1_HUMAN (4-655): 0: 561: 100.00
+	Hs
		209216 TCPE_HUMAN (1-541): 0: 637: 100.00		PRP4_HUMAN (103-320): 3.98e-50: 184: 24.12
+	Hs
		876199 TCPE_HUMAN (1-541): 0: 637: 100.00		NLE1_HUMAN (180-577): 8.26e-44: 165: 15.23
+	Hs
		876112 TCPE_HUMAN (1-541): 0: 637: 100.00		SNR40_HUMAN (181-467): 1.04e-34: 137: 17.67
+	Hs
		875898 TCPE_HUMAN (1-541): 0: 637: 100.00		WDR5_HUMAN (223-467): 9.99e-30: 122: 10.76
+	Hs
		209218 TCPG_HUMAN (14-540): 0: 574: 33.15		PRP4_HUMAN (103-320): 3.98e-50: 184: 24.12
+	Hs
		209325 TCPH_HUMAN (12-539): 0: 572: 29.64		PRP4_HUMAN (103-320): 3.98e-50: 184: 24.12
+	Dm
		1070586 Q7KKI0_DROME (5-533): 0: 584: 71.46		Q0KHS0_DROME (383-648): 1.56e-40: 160: 23.13
+	Hs
		876070 TCPE_HUMAN (1-541): 0: 637: 100.00		POC1A_HUMAN (260-471): 4.03e-15: 79.7: 8.92
+	Hs
		876081 TCPE_HUMAN (1-541): 0: 637: 100.00		POC1B_HUMAN (259-470): 1.37e-11: 69.3: 8.45
+	Sc
		823665 TCPE_YEAST (3-540): 0: 583: 59.89		PRP46_YEAST (11-260): 4.91e-28: 119: 26.98
+	Hs
		882075 TCPG_HUMAN (14-540): 0: 574: 33.15		FBXW7_HUMAN (174-340): 2.65e-30: 128: 15.39
+	Hs
		881861 TCPG_HUMAN (14-540): 0: 574: 33.15		WDR5_HUMAN (223-467): 9.99e-30: 122: 10.76
+	Hs
		845257 TCPG_HUMAN (14-540): 0: 574: 33.15		LIS1_HUMAN (227-534): 8.01e-29: 121: 12.50
+	Hs
		965190 TCPH_HUMAN (12-539): 0: 572: 29.64		WDR5_HUMAN (223-467): 9.99e-30: 122: 10.76
+	Hs
		882038 TCPG_HUMAN (14-540): 0: 574: 33.15		POC1A_HUMAN (260-471): 4.03e-15: 79.7: 8.92
+	Hs
		1334162 TCPH_HUMAN (12-539): 0: 572: 29.64		POC1A_HUMAN (260-471): 4.03e-15: 79.7: 8.92
+	Hs
		882014 TCPG_HUMAN (14-540): 0: 574: 33.15		WDR5B_HUMAN (260-467): 1.34e-12: 71.2: 7.11
+	Hs
		882051 TCPG_HUMAN (14-540): 0: 574: 33.15		POC1B_HUMAN (259-470): 1.37e-11: 69.3: 8.45
+	Hs
		1291941 TCPH_HUMAN (12-539): 0: 572: 29.64		WDR5B_HUMAN (260-467): 1.34e-12: 71.2: 7.11