Protein: PRP46
Pre-mRNA-splicing factor PRP46 (Complexed with CEF1 protein 1) (PRP nineteen-associated complex protein 50) (PRP19-associated complex protein 50) (Pre-mRNA-processing protein 46)

Gene: PRP46
Organism: Saccharomyces cerevisiae S288C
Interactions: 85
UniProt ID: Q12417

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0000974 - Prp19 complex
GO:0005681 - spliceosomal complex
GO:0005737 - cytoplasm
GO:0071013 - catalytic step 2 spliceosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

700167

PRP45
Pre-mRNA-processing protein 45

9

5

Small-scale

0.977

High

917516

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

3

13

High-throughput

0.867

High

744184

BRR2
Pre-mRNA-splicing helicase BRR2

3

20

High-throughput

0.861

High

638093

ISY1
Pre-mRNA-splicing factor ISY1

2

2

High-throughput

0.789

High

672086

BUD31
Pre-mRNA-splicing factor BUD31

2

2

High-throughput

0.789

High

751811

PRP8
Pre-mRNA-splicing factor 8

2

6

High-throughput

0.789

High

780243

SN114
Pre-mRNA-splicing factor SNU114

2

9

High-throughput

0.789

High

664634

PRP22
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22

2

17

Small-scale

0.768

High

1043518

CEF1
Pre-mRNA-splicing factor CEF1

7

11

Small-scale

0.747

High

739226

PRP19
Pre-mRNA-processing factor 19

7

19

Small-scale

0.744

High

1084187

CWC2
Pre-mRNA-splicing factor CWC2

5

3

Small-scale

0.718

High

1084744

CLF1
Pre-mRNA-splicing factor CLF1

5

20

Small-scale

0.713

High

702294

YJU2
Splicing factor YJU2

5

2

Small-scale

0.712

High

796475

SLT11
Pre-mRNA-splicing factor SLT11

4

2

High-throughput

0.697

High

1065584

RU2A
U2 small nuclear ribonucleoprotein A'

4

7

Small-scale

0.686

High

628244

PRP2
Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2

2

17

High-throughput

0.675

High

1037768

CUS1
Cold sensitive U2 snRNA suppressor 1

3

2

High-throughput

0.662

High

817184

RSMB
Small nuclear ribonucleoprotein-associated protein B

3

4

High-throughput

0.656

High

865117

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.646

High

820854

RUXG
Small nuclear ribonucleoprotein G

3

4

High-throughput

0.643

High

933158

RUXF
Small nuclear ribonucleoprotein F

3

3

High-throughput

0.643

High

1065117

NCBP2
Nuclear cap-binding protein subunit 2

3

8

High-throughput

0.640

High

546831

SSB1
Ribosome-associated molecular chaperone SSB1

3

19

High-throughput

0.633

High

1042542

CWC21
Pre-mRNA-splicing factor CWC21

3

0

Small-scale

0.622

High

811199

TCPZ
T-complex protein 1 subunit zeta

1

20

High-throughput

0.618

High

823665

TCPE
T-complex protein 1 subunit epsilon

1

20

High-throughput

0.618

High

590234

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

1

19

High-throughput

0.618

High

829968

PRP17
Pre-mRNA-processing factor 17

1

18

High-throughput

0.618

High

1047399

RSE1
Pre-mRNA-splicing factor RSE1

1

15

High-throughput

0.618

High

1084898

PRP46
Pre-mRNA-splicing factor PRP46

1

16

High-throughput

0.618

High

919741

CWC22
Pre-mRNA-splicing factor CWC22

2

2

High-throughput

0.611

High

1044956

SYF1
Pre-mRNA-splicing factor SYF1

2

19

High-throughput

0.611

High

1054398

SMD2
Small nuclear ribonucleoprotein Sm D2

2

2

High-throughput

0.611

High

746155

PEP12
Syntaxin PEP12

3

1

Small-scale

0.603

High

1055011

SP382
Pre-mRNA-splicing factor SPP382

2

0

High-throughput

0.602

High

1059219

PRP11
Pre-mRNA-splicing factor PRP11

2

3

High-throughput

0.601

High

592593

VATB
V-type proton ATPase subunit B

2

9

High-throughput

0.588

High

1044031

CWC15
Pre-mRNA-splicing factor CWC15

1

0

High-throughput

0.586

High

797701

NTC20
Pre-mRNA-splicing factor NTC20

2

0

High-throughput

0.585

High

919231

SYF2
Pre-mRNA-splicing factor SYF2

2

0

High-throughput

0.585

High

1053569

SN309
Pre-mRNA-splicing factor SNT309

2

0

High-throughput

0.585

High

757559

NCBP1
Nuclear cap-binding protein complex subunit 1

2

2

High-throughput

0.584

High

626933

HSP60
Heat shock protein 60, mitochondrial

1

20

High-throughput

0.578

High

737507

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

2

4

High-throughput

0.567

High

909507

HFM1
ATP-dependent DNA helicase MER3

1

18

Small-scale

0.555

High

528078

HSP72
Heat shock protein SSA2

2

20

High-throughput

0.552

High

923945

CWC25
Pre-mRNA-splicing factor CWC25

2

0

High-throughput

0.547

High

598939

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

5

High-throughput

0.536

High

722374

XPO1
Exportin-1

1

12

High-throughput

0.536

High

826557

MSL1
U2 small nuclear ribonucleoprotein B''

1

20

High-throughput

0.536

High

914891

CWC23
Pre-mRNA-splicing factor CWC23

1

13

High-throughput

0.536

High

797806

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.513

High

1055575

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.513

High

597313

BIP
Endoplasmic reticulum chaperone BiP

1

13

High-throughput

0.500

High

665865

KPC1
Protein kinase C-like 1

1

12

Small-scale

0.481

High

625149

PRP9
Pre-mRNA-splicing factor PRP9

1

2

High-throughput

0.479

High

739288

PRP21
Pre-mRNA-splicing factor PRP21

1

2

High-throughput

0.479

High

826533

IST3
U2 snRNP component IST3

1

12

High-throughput

0.479

High

847848

SMD3
Small nuclear ribonucleoprotein Sm D3

1

15

High-throughput

0.479

High

863107

CWC26
Pre-mRNA-splicing factor CWC26

1

2

High-throughput

0.479

High

892802

SF3B1
U2 snRNP component HSH155

1

15

High-throughput

0.479

High

1036192

SMD1
Small nuclear ribonucleoprotein Sm D1

1

3

High-throughput

0.479

High

1038546

SLU7
Pre-mRNA-splicing factor SLU7

1

1

High-throughput

0.479

High

1060846

PML1
Pre-mRNA leakage protein 1

1

2

High-throughput

0.479

High

1084899

HSH49
Protein HSH49

1

5

High-throughput

0.479

High

438508

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

2

High-throughput

0.470

High

781597

NTR2
Pre-mRNA-splicing factor NTR2

1

0

High-throughput

0.458

High

781985

YK21
Uncharacterized protein YKR041W

1

0

High-throughput

0.458

High

1057308

RDS3
Pre-mRNA-splicing factor RDS3

1

0

High-throughput

0.458

High

367157

ATPB
ATP synthase subunit beta, mitochondrial

1

9

High-throughput

0.457

High

405159

LEU3
3-isopropylmalate dehydrogenase

1

8

High-throughput

0.457

High

453854

PYR1
Multifunctional protein URA2

1

7

High-throughput

0.445

High

525619

HSP71
Heat shock protein SSA1

1

18

High-throughput

0.445

High

742728

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

820178

SSB2
Ribosome-associated molecular chaperone SSB2

1

19

High-throughput

0.445

High

1055040

TDA5
Uncharacterized oxidoreductase TDA5

1

1

Small-scale

0.439

High

826953

DSN1
Kinetochore-associated protein DSN1

1

2

High-throughput

0.437

High

1084491

YRA1
RNA annealing protein YRA1

1

9

High-throughput

0.437

High

863795

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.426

High

823303

JEM1
DnaJ-like chaperone JEM1

1

10

High-throughput

0.407

High

472263

MSS18
Protein MSS18

1

0

High-throughput

0.269

Low

793289

TAT1
Valine/tyrosine/tryptophan amino-acid permease 1

1

0

Small-scale

0.251

Low

1031772

CIK1
Spindle pole body-associated protein CIK1

1

0

High-throughput

0.249

Low

1044854

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025