HitPredict

Interactor 1: AFAD (P55196)
Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)
Gene: AFDN

Interactor 2: PKP4 (Q99569)
Plakophilin-4 (p0071)
Gene: PKP4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0005911 - cell-cell junction GO:0005912 - adherens junction GO:0007267 - cell-cell signaling GO:0030054 - cell junction and 1 others more... GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1824 Hs			1 1192
+	Hs
		876488 AFAD_HUMAN (1-1824): 0: 1279: 100.00		PKP2_HUMAN (156-1014): 1.57e-160: 502: 24.78
+	Hs
		716910 AFAD_HUMAN (1-1824): 0: 1279: 100.00		CTNB1_HUMAN (311-1123): 4.61e-149: 469: 16.00
+	Hs
		542246 AFAD_HUMAN (1-1824): 0: 1279: 100.00		PLAK_HUMAN (316-1101): 3.54e-125: 404: 16.54
+	Hs
		239095 AFAD_HUMAN (1-1824): 0: 1279: 100.00		CTND1_HUMAN (26-872): 2.01e-72: 263: 13.69
+	Hs
		1066575 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		PKP4_HUMAN (1-1192): 0: 1148: 100.00
+	Hs
		942372 DLG4_HUMAN (1002-1238): 1.07e-27: 123: 17.51		PKP4_HUMAN (1-1192): 0: 1148: 100.00
+	Hs
		1050039 SCRIB_HUMAN (989-1133): 4.27e-22: 106: 26.85		PKP4_HUMAN (1-1192): 0: 1148: 100.00
+	Ce
		218226 Q9BIC1_CAEEL (9-1580): 0: 706: 25.74		HMP2_CAEEL (385-1063): 4.09e-99: 332: 15.97
+	Hs
		942400 DLG4_HUMAN (1002-1238): 1.07e-27: 123: 17.51		CTND2_HUMAN (1-1192): 0: 862: 48.99
+	Hs
		1050093 SCRIB_HUMAN (989-1133): 4.27e-22: 106: 26.85		CTND2_HUMAN (1-1192): 0: 862: 48.99
+	Hs
		717426 MYO5B_HUMAN (102-939): 4.92e-118: 416: 14.72		CTNB1_HUMAN (311-1123): 4.61e-149: 469: 16.00
+	Hs
		1066587 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		PKP2_HUMAN (156-1014): 1.57e-160: 502: 24.78
+	Hs
		1066931 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		PKP3_HUMAN (218-1014): 2.04e-152: 478: 26.92
+	Hs
		717094 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		CTNB1_HUMAN (311-1123): 4.61e-149: 469: 16.00
+	Hs
		542329 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		PLAK_HUMAN (316-1101): 3.54e-125: 404: 16.54
+	Hs
		717363 GOPC_HUMAN (744-1099): 5.55e-40: 157: 14.72		CTNB1_HUMAN (311-1123): 4.61e-149: 469: 16.00
+	Mm
		970142 DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51		CTNB1_MOUSE (311-1123): 2.73e-149: 469: 16.00
+	Hs
		717076 SCRIB_HUMAN (989-1133): 4.27e-22: 106: 26.85		CTNB1_HUMAN (311-1123): 4.61e-149: 469: 16.00
+	Hs
		239135 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		CTND1_HUMAN (26-872): 2.01e-72: 263: 13.69
+	Ce
		86391 C1P633_CAEEL (927-1284): 1.52e-19: 98.1: 18.23		H2L2I2_CAEEL (356-1063): 8.2e-106: 351: 16.15