Protein: K22O
Keratin, type II cytoskeletal 2 oral (Cytokeratin-2P) (CK-2P) (K2P) (Keratin-76) (K76) (Type-II keratin Kb9)

Gene: K22O, KRT76
Organism: Homo sapiens
Interactions: 88
UniProt ID: Q01546

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0005882 - intermediate filament
GO:0007010 - cytoskeleton organization
GO:0030280 - structural constituent of skin epidermis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

341757

K2C75
Keratin, type II cytoskeletal 75

3

20

High-throughput

0.843

High

476299

K1C16
Keratin, type I cytoskeletal 16

3

20

High-throughput

0.843

High

777388

K1C20
Keratin, type I cytoskeletal 20

3

20

High-throughput

0.843

High

1030986

K1H1
Keratin, type I cuticular Ha1

2

20

High-throughput

0.794

High

227211

KRT86
Keratin, type II cuticular Hb6

2

18

High-throughput

0.783

High

300565

KRT36
Keratin, type I cuticular Ha6

2

20

High-throughput

0.783

High

300644

KRT37
Keratin, type I cuticular Ha7

2

20

High-throughput

0.783

High

300745

KRT38
Keratin, type I cuticular Ha8

2

20

High-throughput

0.783

High

1030993

K1C40
Keratin, type I cytoskeletal 40

2

20

High-throughput

0.783

High

1030994

K1C39
Keratin, type I cytoskeletal 39

2

20

High-throughput

0.783

High

1031000

K1C27
Keratin, type I cytoskeletal 27

2

20

High-throughput

0.783

High

1031002

K1C25
Keratin, type I cytoskeletal 25

2

20

High-throughput

0.783

High

475561

K1C19
Keratin, type I cytoskeletal 19

2

20

High-throughput

0.757

High

618021

K1C15
Keratin, type I cytoskeletal 15

2

20

High-throughput

0.757

High

566257

K1C13
Keratin, type I cytoskeletal 13

1

20

High-throughput

0.621

High

1030984

KT33B
Keratin, type I cuticular Ha3-II

1

20

High-throughput

0.621

High

1030985

K1H2
Keratin, type I cuticular Ha2

1

20

High-throughput

0.621

High

1030999

K1C28
Keratin, type I cytoskeletal 28

1

20

High-throughput

0.621

High

1031001

K1C26
Keratin, type I cytoskeletal 26

1

20

High-throughput

0.621

High

1031010

KRT35
Keratin, type I cuticular Ha5

1

20

High-throughput

0.621

High

385089

K1C14
Keratin, type I cytoskeletal 14

1

20

High-throughput

0.618

High

385260

K2C6A
Keratin, type II cytoskeletal 6A

1

20

High-throughput

0.618

High

436845

K1C18
Keratin, type I cytoskeletal 18

1

20

High-throughput

0.618

High

437146

K2C8
Keratin, type II cytoskeletal 8

1

19

High-throughput

0.618

High

474622

VIME
Vimentin

1

20

High-throughput

0.618

High

475753

K2C7
Keratin, type II cytoskeletal 7

1

20

High-throughput

0.618

High

566136

K1C10
Keratin, type I cytoskeletal 10

1

20

High-throughput

0.618

High

566360

K2C5
Keratin, type II cytoskeletal 5

1

20

High-throughput

0.618

High

606102

DESM
Desmin

1

20

High-throughput

0.618

High

833251

PERI
Peripherin

1

20

High-throughput

0.618

High

1030977

K1C17
Keratin, type I cytoskeletal 17

1

20

High-throughput

0.618

High

1031012

K1C12
Keratin, type I cytoskeletal 12

1

20

High-throughput

0.618

High

1031019

KRT84
Keratin, type II cuticular Hb4

1

20

High-throughput

0.618

High

169516

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

6

High-throughput

0.606

High

180271

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

2

1

High-throughput

0.606

High

571930

TRI27
Zinc finger protein RFP

2

8

High-throughput

0.606

High

783239

TRI23
E3 ubiquitin-protein ligase TRIM23

2

6

High-throughput

0.606

High

1030988

CDC37
Hsp90 co-chaperone Cdc37

2

1

High-throughput

0.606

High

1030991

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

14

High-throughput

0.606

High

1031004

EXOC8
Exocyst complex component 8

2

1

High-throughput

0.606

High

1031006

ZN655
Zinc finger protein 655

2

4

High-throughput

0.606

High

1031008

IKBD
NF-kappa-B inhibitor delta

2

4

High-throughput

0.606

High

1031013

KIFC3
Kinesin-like protein KIFC3

2

9

High-throughput

0.606

High

1031020

AIRIM
AFG2-interacting ribosome maturation factor

2

1

High-throughput

0.606

High

1031022

IPO11
Importin-11

2

4

High-throughput

0.606

High

1031023

TRIM1
Probable E3 ubiquitin-protein ligase MID2

2

20

High-throughput

0.606

High

1031025

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

2

2

High-throughput

0.606

High

1030995

FOXR2
Forkhead box protein R2

2

0

High-throughput

0.580

High

1030996

DPPA3
Developmental pluripotency-associated protein 3

2

0

High-throughput

0.580

High

337214

LCA5L
Lebercilin-like protein

2

2

High-throughput

0.553

High

965433

LMO4
LIM domain transcription factor LMO4

2

7

High-throughput

0.553

High

1030989

CCD57
Coiled-coil domain-containing protein 57

2

4

High-throughput

0.553

High

1030992

TENS2
Tensin-2

2

3

High-throughput

0.553

High

1031005

CF206
Cilia- and flagella-associated protein 206

2

1

High-throughput

0.553

High

1031007

IQUB
IQ motif and ubiquitin-like domain-containing protein

2

1

High-throughput

0.553

High

1031009

CA216
UPF0500 protein C1orf216

2

2

High-throughput

0.553

High

1031014

TRI54
Tripartite motif-containing protein 54

2

20

High-throughput

0.553

High

1031015

TSG10
Testis-specific gene 10 protein

2

8

High-throughput

0.553

High

1031021

RSP14
Radial spoke head 14 homolog

2

4

High-throughput

0.553

High

765404

BMI1
Polycomb complex protein BMI-1

1

14

High-throughput

0.536

High

1030979

CUL2
Cullin-2

1

20

High-throughput

0.536

High

1030980

CUL3
Cullin-3

1

20

High-throughput

0.536

High

1030981

CUL4A
Cullin-4A

1

20

High-throughput

0.536

High

1030982

CUL4B
Cullin-4B

1

20

High-throughput

0.536

High

1030987

NEDD8
Ubiquitin-like protein NEDD8

1

3

High-throughput

0.536

High

1030998

CSN6
COP9 signalosome complex subunit 6

1

9

High-throughput

0.536

High

1031003

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

5

High-throughput

0.536

High

1031011

CSN5
COP9 signalosome complex subunit 5

1

15

High-throughput

0.536

High

277650

H2AY
Core histone macro-H2A.1

1

1

High-throughput

0.515

High

69372

WASH1
WASH complex subunit 1

1

2

High-throughput

0.481

High

241427

PRKN
E3 ubiquitin-protein ligase parkin

1

15

High-throughput

0.479

High

324804

HEXI1
Protein HEXIM1

1

18

High-throughput

0.479

High

841606

LIFR
Leukemia inhibitory factor receptor

1

3

High-throughput

0.479

High

855591

CRK
Adapter molecule crk

1

20

High-throughput

0.479

High

862048

YAP1
Transcriptional coactivator YAP1

1

19

High-throughput

0.479

High

1030978

TFCP2
Alpha-globin transcription factor CP2

1

4

High-throughput

0.479

High

1030983

DCTN1
Dynactin subunit 1

1

15

High-throughput

0.479

High

1030990

LARP7
La-related protein 7

1

10

High-throughput

0.479

High

1030997

MEPCE
7SK snRNA methylphosphate capping enzyme

1

10

High-throughput

0.479

High

1031018

RN208
RING finger protein 208

1

20

Small-scale

0.479

High

567373

TCTP
Translationally-controlled tumor protein

1

2

Small-scale

0.445

High

952112

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

20

High-throughput

0.445

High

1031016

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

20

High-throughput

0.445

High

1031017

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

20

High-throughput

0.445

High

192485

INSI1
Insulin-induced gene 1 protein

1

6

High-throughput

0.437

High

1031024

PHTF1
Protein PHTF1

1

8

High-throughput

0.437

High

1031026

INSI2
Insulin-induced gene 2 protein

1

6

High-throughput

0.437

High

220233

FRS3
Fibroblast growth factor receptor substrate 3

2

0

High-throughput

0.316

High


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Last updated: 11Aug2025