HitPredict

Interactor 1: CLK1 (P49759)
Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1)
Gene: CLK1

Interactor 2: SRSF3 (P84103)
Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3)
Gene: SRSF3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.80	0.822

Property	Details
Experiments	12890497, 32296183, 33961781, unassigned1304, unassigned3799
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 484 Hs			1 164
+	Hs
		889428 CLK1_HUMAN (1-484): 3.52e-162: 469: 100.00		SRSF7_HUMAN (9-106): 1.03e-30: 112: 67.35
+	Hs
		889406 CLK1_HUMAN (1-484): 3.52e-162: 469: 100.00		SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65
+	Hs
		889413 CLK1_HUMAN (1-484): 3.52e-162: 469: 100.00		SRSF5_HUMAN (10-112): 2.1e-24: 97: 44.34
+	Hs
		284094 CLK1_HUMAN (1-484): 3.52e-162: 469: 100.00		SRS10_HUMAN (1-164): 2.26e-24: 96.6: 32.54
+	Hs
		889407 CLK1_HUMAN (1-484): 3.52e-162: 469: 100.00		SRSF4_HUMAN (11-112): 3.44e-16: 76.6: 39.22
+	Hs
		889414 CLK1_HUMAN (1-484): 3.52e-162: 469: 100.00		SRSF6_HUMAN (11-88): 3.88e-16: 75.8: 47.44
+	Hs
		1061160 CLK4_HUMAN (1-482): 2.32e-145: 426: 78.72		SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65
+	Hs
		1099261 CLK4_HUMAN (1-482): 2.32e-145: 426: 78.72		SRSF5_HUMAN (10-112): 2.1e-24: 97: 44.34
+	Hs
		284233 CLK4_HUMAN (1-482): 2.32e-145: 426: 78.72		SRS10_HUMAN (1-164): 2.26e-24: 96.6: 32.54
+	Hs
		889574 CLK2_HUMAN (1-481): 5.01e-134: 398: 52.98		SRSF7_HUMAN (9-106): 1.03e-30: 112: 67.35
+	Hs
		667882 CDK2_HUMAN (158-484): 7.76e-137: 397: 25.45		SRSF7_HUMAN (9-106): 1.03e-30: 112: 67.35
+	Hs
		1062119 CLK4_HUMAN (1-482): 2.32e-145: 426: 78.72		SRSF4_HUMAN (11-112): 3.44e-16: 76.6: 39.22
+	Hs
		1099545 CLK4_HUMAN (1-482): 2.32e-145: 426: 78.72		SRSF6_HUMAN (11-88): 3.88e-16: 75.8: 47.44
+	Hs
		889552 CLK2_HUMAN (1-481): 5.01e-134: 398: 52.98		SRSF3_HUMAN (1-164): 4.93e-28: 103: 100.00
+	Hs
		889557 CLK2_HUMAN (1-481): 5.01e-134: 398: 52.98		SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65
+	Hs
		284095 CLK2_HUMAN (1-481): 5.01e-134: 398: 52.98		SRS10_HUMAN (1-164): 2.26e-24: 96.6: 32.54
+	Hs
		550181 CLK2_HUMAN (1-481): 5.01e-134: 398: 52.98		PABP1_HUMAN (1-91): 1.19e-20: 89.6: 25.77
+	Hs
		550125 CDK2_HUMAN (158-484): 7.76e-137: 397: 25.45		PABP1_HUMAN (1-91): 1.19e-20: 89.6: 25.77
+	Hs
		889558 CLK2_HUMAN (1-481): 5.01e-134: 398: 52.98		SRSF4_HUMAN (11-112): 3.44e-16: 76.6: 39.22
+	Hs
		889562 CLK2_HUMAN (1-481): 5.01e-134: 398: 52.98		SRSF6_HUMAN (11-88): 3.88e-16: 75.8: 47.44