HitPredict

Interactor 1: CLK1 (P49759)
Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1)
Gene: CLK1

Interactor 2: SRSF7 (Q16629)
Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7)
Gene: SRSF7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.897

Property	Details
Experiments	26167880, 32296183, 33961781, unassigned1304
Identification Methods	enzymatic study, two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 484 Hs			1 238
+	Hs
		889474 CLK1_HUMAN (1-484): 3.52e-162: 469: 100.00		SRS12_HUMAN (1-218): 8.53e-28: 108: 32.60
+	Hs
		889396 CLK1_HUMAN (1-484): 3.52e-162: 469: 100.00		SRSF3_HUMAN (5-154): 2.54e-24: 96.5: 55.33
+	Hs
		889406 CLK1_HUMAN (1-484): 3.52e-162: 469: 100.00		SRSF1_HUMAN (10-81): 4.53e-21: 90.3: 48.65
+	Hs
		1061160 CLK4_HUMAN (1-482): 2.32e-145: 426: 78.72		SRSF1_HUMAN (10-81): 4.53e-21: 90.3: 48.65
+	Hs
		889625 CLK2_HUMAN (1-481): 5.01e-134: 398: 52.98		SRS12_HUMAN (1-218): 8.53e-28: 108: 32.60
+	Hs
		889574 CLK2_HUMAN (1-481): 5.01e-134: 398: 52.98		SRSF7_HUMAN (1-238): 1e-27: 107: 100.00
+	Hs
		667882 CDK2_HUMAN (158-484): 7.76e-137: 397: 25.45		SRSF7_HUMAN (1-238): 1e-27: 107: 100.00
+	Hs
		462299 CLK2_HUMAN (1-481): 5.01e-134: 398: 52.98		HNRPC_HUMAN (3-186): 3.01e-24: 99: 22.58
+	Hs
		462244 CDK2_HUMAN (158-484): 7.76e-137: 397: 25.45		HNRPC_HUMAN (3-186): 3.01e-24: 99: 22.58
+	Hs
		889552 CLK2_HUMAN (1-481): 5.01e-134: 398: 52.98		SRSF3_HUMAN (5-154): 2.54e-24: 96.5: 55.33
+	Hs
		889557 CLK2_HUMAN (1-481): 5.01e-134: 398: 52.98		SRSF1_HUMAN (10-81): 4.53e-21: 90.3: 48.65
+	Hs
		550181 CLK2_HUMAN (1-481): 5.01e-134: 398: 52.98		PABP1_HUMAN (6-96): 2.86e-19: 88.2: 22.34
+	Hs
		550125 CDK2_HUMAN (158-484): 7.76e-137: 397: 25.45		PABP1_HUMAN (6-96): 2.86e-19: 88.2: 22.34
+	Hs
		889743 CLK3_HUMAN (1-480): 7.81e-126: 377: 48.35		SRSF7_HUMAN (1-238): 1e-27: 107: 100.00
+	Hs
		462300 CLK3_HUMAN (1-480): 7.81e-126: 377: 48.35		HNRPC_HUMAN (3-186): 3.01e-24: 99: 22.58
+	Hs
		889711 CLK3_HUMAN (1-480): 7.81e-126: 377: 48.35		SRSF3_HUMAN (5-154): 2.54e-24: 96.5: 55.33
+	Hs
		889723 CLK3_HUMAN (1-480): 7.81e-126: 377: 48.35		PABP4_HUMAN (6-163): 5.37e-21: 93.2: 16.15
+	Hs
		668018 CDK2_HUMAN (158-484): 7.76e-137: 397: 25.45		RBM4_HUMAN (12-89): 4.46e-14: 72.2: 33.33
+	Hs
		889716 CLK3_HUMAN (1-480): 7.81e-126: 377: 48.35		SRSF1_HUMAN (10-81): 4.53e-21: 90.3: 48.65
+	Hs
		550182 CLK3_HUMAN (1-480): 7.81e-126: 377: 48.35		PABP1_HUMAN (6-96): 2.86e-19: 88.2: 22.34