HitPredict

Interactor 1: PSA6 (P60900)
Proteasome subunit alpha type-6 (27 kDa prosomal protein) (PROS-27) (p27K) (Macropain iota chain) (Multicatalytic endopeptidase complex iota chain) (Proteasome iota chain)
Gene: PSMA6

Interactor 2: CUL1 (Q13616)
Cullin-1 (CUL-1)
Gene: CUL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.639

Property	Details
Experiments	16759355, 21145461
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 246 Hs			1 776
+	Hs
		637680 PSA2_HUMAN (7-243): 8.3e-104: 302: 35.44		CUL1_HUMAN (1-776): 0: 911: 100.00
+	Hs
		156283 PSA7_HUMAN (9-240): 1.34e-97: 286: 33.62		CUL1_HUMAN (1-776): 0: 911: 100.00
+	Hs
		656219 PSA5_HUMAN (1-242): 4.79e-96: 282: 25.91		CUL1_HUMAN (1-776): 0: 911: 100.00
+	Hs
		637411 PSA1_HUMAN (1-245): 2.4e-94: 279: 25.91		CUL1_HUMAN (1-776): 0: 911: 100.00
+	Hs
		638125 PSA4_HUMAN (6-239): 5.7e-93: 275: 32.35		CUL1_HUMAN (1-776): 0: 911: 100.00
+	Hs
		637681 PSA2_HUMAN (7-243): 8.3e-104: 302: 35.44		CUL4A_HUMAN (7-776): 0: 781: 30.41
+	Hs
		156284 PSA7_HUMAN (9-240): 1.34e-97: 286: 33.62		CUL3_HUMAN (9-776): 0: 748: 30.47
+	Hs
		656220 PSA5_HUMAN (1-242): 4.79e-96: 282: 25.91		CUL3_HUMAN (9-776): 0: 748: 30.47