HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: PAK1 (Q13153)
Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK)
Gene: PAK1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.990

The method score is based on:

Property Details
Experiments 31478661, 21048135, 9535855, 31871319, 20936779, 10360579, 10684602, 10802735, 24276241, 18057010, 15548653, 18426980, 12650940, 16678097, 23455922, 25150978, 10224076, 11157984, 23175184, 21029865 and 6 others

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Identification Methods pull down, fluorescent resonance energy transfer, affinity chromatography technology, two hybrid, x-ray crystallography, two hybrid pooling approach, anti tag coimmunoprecipitation, tandem affinity purification, imaging technique
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains PBD~Ras, Pkinase~Ras
Common GO terms GO:0005737 - cytoplasm
GO:0005813 - centrosome
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0005911 - cell-cell junction
and 6 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 191
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024