HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: SEPT2 (Q15019)
Septin-2 (Neural precursor cell expressed developmentally down-regulated protein 5) (NEDD-5)
Gene: SEPTIN2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	31478661, 31871319
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003924 - GTPase activity GO:0005525 - GTP binding GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0030496 - midbody and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 191 Hs			1 361
+	Hs
		951004 RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73		SEPT2_HUMAN (1-361): 0: 533: 100.00
+	Hs
		894054 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		SEPT7_HUMAN (11-357): 2.78e-171: 485: 53.61
+	Hs
		894272 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		SEPT8_HUMAN (3-348): 2.74e-162: 464: 39.54
+	Hs
		1330963 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		SEP10_HUMAN (14-357): 7.49e-159: 454: 38.00
+	Hs
		894560 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		SEPT9_HUMAN (2-320): 2.97e-159: 460: 45.68
+	Hs
		925687 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		SEP10_HUMAN (14-357): 7.49e-159: 454: 38.00
+	Hs
		894495 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		SEP11_HUMAN (8-348): 3.99e-161: 459: 39.83
+	Hs
		893995 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		SEPT6_HUMAN (14-348): 5.19e-160: 457: 40.24
+	Hs
		894532 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		SEP10_HUMAN (14-357): 7.49e-159: 454: 38.00
+	Hs
		1049000 RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82		SEPT6_HUMAN (14-348): 5.19e-160: 457: 40.24