HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: DOCK8 (Q8NF50)
Dedicator of cytokinesis protein 8
Gene: DOCK8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.757

Property	Details
Experiments	31871319, 15304341
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	DHR-2_Lobe_B~Ras, DHR-2_Lobe_C~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane GO:0031256 - leading edge membrane and 1 others more... GO:0036336 - dendritic cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 2099
+	Hs
		925448 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		DOCK8_HUMAN (1-2099): 0: 2775: 100.00
+	Hs
		925526 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		DOCK7_HUMAN (7-2092): 0: 2471: 55.37
+	Hs
		925518 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		DOCK6_HUMAN (4-2092): 0: 2401: 51.16
+	Hs
		925429 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		DOCK4_HUMAN (560-867): 5.36e-62: 238: 20.43
+	Hs
		564557 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		DOC11_HUMAN (22-177): 2.25e-43: 176: 22.50
+	Hs
		564671 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		DOCK9_HUMAN (5-177): 2.21e-40: 167: 19.89
+	Hs
		1127531 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		DOC11_HUMAN (22-177): 2.25e-43: 176: 22.50
+	Hs
		925332 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		DOC11_HUMAN (22-177): 2.25e-43: 176: 22.50
+	Mm
		57052 CDC42_MOUSE (1-191): 4.96e-82: 243: 100.00		DOC11_MOUSE (22-177): 8.02e-44: 178: 22.50
+	Hs
		1317682 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		DOCK9_HUMAN (5-177): 2.21e-40: 167: 19.89
+	Hs
		894099 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		DOC11_HUMAN (22-177): 2.25e-43: 176: 22.50
+	Hs
		925588 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		DOCK9_HUMAN (5-177): 2.21e-40: 167: 19.89
+	Hs
		925425 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		DOCK3_HUMAN (560-867): 4.26e-35: 149: 18.63
+	Mm
		101404 CDC42_MOUSE (1-191): 4.96e-82: 243: 100.00		F8VPN7_MOUSE (13-177): 5.42e-32: 139: 17.96
+	Hs
		925276 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		DOCK1_HUMAN (560-867): 5.67e-28: 126: 19.33
+	Mm
		925807 RAC1_MOUSE (1-191): 1.75e-84: 249: 70.31		DOCK1_MOUSE (560-867): 7.24e-28: 126: 19.02
+	Hs
		925620 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		DOCK5_HUMAN (560-867): 2.82e-24: 114: 17.49
+	Hs
		925486 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		DOCK2_HUMAN (560-865): 3.25e-21: 104: 16.67
+	Hs
		894298 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		DOC10_HUMAN (4-177): 1.06e-21: 105: 18.64
+	Mm
		892732 CDC42_MOUSE (1-191): 4.96e-82: 243: 100.00		DOC10_MOUSE (4-177): 2.8e-21: 104: 18.64